Chromosome 8 Open Reading Frame 76 (C8orf76) Co-Expressed with Cyclin-Dependent Kinase 4 (CDK4) as a Prognostic Indicator of Colorectal Cancer.
- Author:
Shang GUO
1
;
Cheng Cheng LIU
1
;
Zi Feng ZHAO
1
;
Zhong Xin LI
1
;
Xia JIANG
1
;
Zeng Ren ZHAO
1
Author Information
- Publication Type:Journal Article
- Keywords: C8orf76; CDK4; Colorectal cancer; Nomogram; Prognosis signature
- MeSH: Humans; Colorectal Neoplasms/diagnosis*; Cyclin-Dependent Kinase 4/metabolism*; Prognosis; Male; Female; Middle Aged; Biomarkers, Tumor/genetics*; Aged; Cell Line, Tumor; Gene Expression Regulation, Neoplastic
- From: Biomedical and Environmental Sciences 2025;38(8):977-987
- CountryChina
- Language:English
-
Abstract:
OBJECTIVE:To explore the correlation between chromosome 8 open reading frame 76 (C8orf76) and cyclin-dependent kinase 4 (CDK4) and the potential predictive effect of C8orf76 and CDK4 on the prognosis of colorectal cancer (CRC).
METHODS:We constructed a protein-protein interaction network of C8orf76-related genes and analyzed the prognostic signatures of C8orf76 and CDK4. Clinicopathological features of C8orf76 and CDK4 were visualized using a nomogram.
RESULTS:C8orf76 and CDK4 levels were positively correlated in two independent human CRC cohorts ( n = 83 and n = 597). A consistent positive correlation was observed between C8orf76 and CDK4 expression in the CRC cell lines. The nomogram included prognostic genes (C8orf76 and CDK4) and pathological N and M stages. The concordance index (C-index) in our cohort was 0.776, which suggests that the ability of the indicators to predict the overall survival of patients with CRC in our cohort was strong.
CONCLUSION:We found that C8orf76 was positively correlated with CDK4 in both the cohorts as well as in CRC cell lines. Therefore, C8orf76 and CDK4 can be used as potential biomarkers to predict the prognosis of CRC.
