Association of Longitudinal Change in Fasting Blood Glucose with Risk of Cerebral Infarction in a Patients with Diabetes.

Tai Yang LUO; Xuan DENG; Xue Yu CHEN; Yu He LIU; Shuo Hua CHEN; Hao Ran SUN; Zi Wei YIN; Shou Ling WU; Yong ZHOU; Xing Dong ZHENG

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Association of Longitudinal Change in Fasting Blood Glucose with Risk of Cerebral Infarction in a Patients with Diabetes.

Author: Tai Yang LUO ¹ ; Xuan DENG ² ; Xue Yu CHEN ³ ; Yu He LIU ² ; Shuo Hua CHEN ⁴ ; Hao Ran SUN ⁵ ; Zi Wei YIN ⁶ ; Shou Ling WU ⁴ ; Yong ZHOU ² ; Xing Dong ZHENG ²
Author Information

1. Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases, Beijing 100029, China.
2. Clinical Research Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
3. Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China.
4. Cardiology Department, Kailuan General Hospital, Tangshan 063000, Hebei, China.
5. Vanke School of Public Health, Tsinghua University, Beijing 100084, China;Institute of Healthy China, Tsinghua University, Beijing 100084, China.
6. Clinical Research Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China;Administrative Office, Total Quality Management Office, Total Quality Management Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
Publication Type:Journal Article
Keywords: Cerebral infarction; Diabetes; Fasting blood glucose trajectory; Glycemic control
MeSH: Humans; Cerebral Infarction/blood*; Middle Aged; Male; Female; Blood Glucose/analysis*; Fasting/blood*; Aged; Prospective Studies; Risk Factors; Diabetes Mellitus/blood*; Adult; Proportional Hazards Models
From: Biomedical and Environmental Sciences 2025;38(8):926-934
CountryChina
Language:English
Abstract: OBJECTIVE:To investigate the association between long-term glycemic control and cerebral infarction risk in patients with diabetes through a large-scale cohort study.
METHODS:This prospective, community-based cohort study included 12,054 patients with diabetes. From 2006 to 2012, 38,272 fasting blood glucose (FBG) measurements were obtained from these participants. FBG trajectory patterns were generated using latent mixture modelling. Cox proportional hazards models were applied to assess the subsequent risk of cerebral infarction associated with different FBG trajectory patterns.
RESULTS:At baseline, the mean age of the participants was 55.2 years. Four distinct FBG trajectories were identified based on FBG concentrations and their changes over the 6-year follow-up period. After a median follow-up of 6.9 years, 786 cerebral infarction events were recorded. Different trajectory patterns were associated with significantly varied outcome risks (Log-Rank P < 0.001). Compared with the low-stability group, Hazard Ratio ( HR) adjusted for potential confounders were 1.37 for the moderate-increasing group, 1.23 for the elevated-decreasing group, and 2.08 for the elevated-stable group.
CONCLUSION:Sustained high FBG levels were found to play a critical role in the development of ischemic stroke among patients with diabetes. Controlling FBG levels may reduce the risk of cerebral infarction.