A Retrospective Study of Pregnancy and Fetal Outcomes in Mothers with Hepatitis C Viremia.

Wen DENG; Zi Yu ZHANG; Xin Xin LI; Ya Qin ZHANG; Wei Hua CAO; Shi Yu WANG; Xin WEI; Zi Xuan GAO; Shuo Jie WANG; Lin Mei YAO; Lu ZHANG; Hong Xiao HAO; Xiao Xue CHEN; Yuan Jiao GAO; Wei YI; Yao XIE; Ming Hui LI

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A Retrospective Study of Pregnancy and Fetal Outcomes in Mothers with Hepatitis C Viremia.

Author: Wen DENG ¹ ; Zi Yu ZHANG ¹ ; Xin Xin LI ¹ ; Ya Qin ZHANG ¹ ; Wei Hua CAO ¹ ; Shi Yu WANG ¹ ; Xin WEI ¹ ; Zi Xuan GAO ¹ ; Shuo Jie WANG ¹ ; Lin Mei YAO ¹ ; Lu ZHANG ¹ ; Hong Xiao HAO ¹ ; Xiao Xue CHEN ¹ ; Yuan Jiao GAO ¹ ; Wei YI ² ; Yao XIE ³ ; Ming Hui LI ³
Author Information

1. Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China;HBV Infection, Clinical Cure and Immunology Joint Laboratory for Clinical Medicine, Capital Medical University, Beijing 100015, China.
2. Department of Gynecology and Obstetrics, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
3. Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China;HBV Infection, Clinical Cure and Immunology Joint Laboratory for Clinical Medicine, Capital Medical University, Beijing 100015, China;Department of Hepatology Division 2, Peking University Ditan Teaching Hospital, Beijing 100015, China.
Publication Type:Journal Article
Keywords: Chronic hepatitis C; Hepatitis C virus; Neonatal jaundice; Pregnancy
MeSH: Humans; Female; Pregnancy; Adult; Pregnancy Complications, Infectious/epidemiology*; Retrospective Studies; Pregnancy Outcome; Infant, Newborn; Viremia/virology*; Hepatitis C; Hepacivirus/physiology*; Hepatitis C, Chronic/virology*; Young Adult; Alanine Transaminase/blood*
From: Biomedical and Environmental Sciences 2025;38(7):829-839
CountryChina
Language:English
Abstract: OBJECTIVE:To investigate chronic hepatitis C virus (HCV) infection's effect on gestational liver function, pregnancy and delivery complications, and neonatal development.
METHODS:A total of 157 HCV antibody-positive (anti-HCV[+]) and HCV RNA(+) patients (Group C) and 121 anti-HCV(+) and HCV RNA(-) patients (Group B) were included as study participants, while 142 anti-HCV(-) and HCV RNA(-) patients (Group A) were the control group. Data on biochemical indices during pregnancy, pregnancy complications, delivery-related information, and neonatal complications were also collected.
RESULTS:Elevated alanine aminotransferase (ALT) rates in Group C during early, middle, and late pregnancy were 59.87%, 43.95%, and 42.04%, respectively-significantly higher than Groups B (26.45%, 15.70%, 10.74%) and A (23.94%, 19.01%, 6.34%) ( P < 0.05). Median ALT levels in Group C were significantly higher than in Groups A and B at all pregnancy stages ( P < 0.05). No significant differences were found in neonatal malformation rates across groups ( P > 0.05). However, neonatal jaundice incidence was significantly greater in Group C (75.16%) compared to Groups A (42.25%) and B (57.02%) ( χ ² = 33.552, P < 0.001). HCV RNA positivity during pregnancy was an independent risk factor for neonatal jaundice ( OR = 2.111, 95% CI 1.242-3.588, P = 0.006).
CONCLUSIONS:Chronic HCV infection can affect the liver function of pregnant women, but does not increase the pregnancy or delivery complication risks. HCV RNA(+) is an independent risk factor for neonatal jaundice.