Advancements in Mpox Vaccine Development: A Comprehensive Review of Global Progress and Recent Data.
- Author:
Yu Qian ZHAI
1
;
Yi Ze HAN
1
;
Wen Ling WANG
1
;
Wen Jie TAN
1
Author Information
- Publication Type:Review
- Keywords: Mpox vaccine; Mpox virus; Smallpox vaccine; Vaccinia virus
- MeSH: Humans; Vaccine Development; Smallpox Vaccine; Smallpox/epidemiology*; Mpox, Monkeypox
- From: Biomedical and Environmental Sciences 2025;38(2):248-254
- CountryChina
- Language:English
- Abstract: Since May 2022, a severe global Mpox epidemic has underscored the urgent need for a preventative vaccine. On September 16, 2022, the mainland of China reported its first case of imported Mpox, which was subsequently followed by a significant rise in domestic infections commencing from June 2023. This alarming trend has escalated the likelihood of localized outbreaks and covert transmission, posing a heightened risk to public health. Notably, the United States, many European countries, and Japan have approved the use of smallpox vaccines for Mpox prevention and emergency vaccination post-exposure, based on their cross-protection efficacy. In recent years, virology research has broadened its scope to include investigations into various novel vaccine approaches, such as nucleic acid-based vaccines, protein subunit vaccines, and epitope peptide vaccines, and other related methodologies. This review offers a thorough examination of the current global landscape of Mpox prevalence, delves into the advancements in Mpox vaccine development, and highlights the progress achieved in Mpox vaccine research, serving as a valuable resource and providing technical insights essential for the effective prevention and control of Mpox.
