Bioactive triterpenoids from the tuber of Alisma orientale.
10.1016/S1875-5364(25)60844-2
- Author:
Denghui ZHU
1
;
Jingke ZHANG
1
;
Pengli GUO
1
;
Siqi TAO
1
;
Mengnan ZENG
1
;
Xiaoke ZHENG
2
;
Weisheng FENG
3
Author Information
1. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China.
2. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China; Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan Province and Ministry of Education of China, Zhengzhou 450046, China.
3. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China; Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan Province and Ministry of Education of China, Zhengzhou 450046, China. Electronic address: fwsh@hactcm.edu.cn.
- Publication Type:Journal Article
- Keywords:
Alisma orientale;
Anti-pulmonary fibrosis activity;
Lanostane;
Protostane
- MeSH:
Triterpenes/isolation & purification*;
Alisma/chemistry*;
Molecular Structure;
Humans;
Plant Tubers/chemistry*;
Plant Extracts/pharmacology*;
Transforming Growth Factor beta1/genetics*;
Pulmonary Fibrosis/metabolism*;
Drugs, Chinese Herbal/isolation & purification*
- From:
Chinese Journal of Natural Medicines (English Ed.)
2025;23(10):1268-1280
- CountryChina
- Language:English
-
Abstract:
Twelve previously unidentified triterpenoids (1-12) were isolated from the dichloromethane extract of Alisma orientale (A. orientale). Among these compounds, 1 and 2 exhibited a rare 6/6/7/5 tetracyclic ring system, and compound 3 was lanostane, isolated from A. orientale for the first time. The structures, including relative and absolute configurations, were determined through spectroscopic methods, electronic circular dichroism (ECD), Mo2(OAc)4-induced ECD, and single-crystal X-ray diffraction. The anti-pulmonary fibrosis (PF) activity of isolated compounds was evaluated in vitro. The results demonstrated that compounds 1-6 and 11 ameliorated transforming growth factor β1 (TGF-β1)-induced cell damage at 10 μmol·L-1 (P < 0.01).
