New diterpenoids from Euphorbia wallichii with antioxidant activity.
10.1016/S1875-5364(25)60859-4
- Author:
Yali WANG
1
;
Juan CHEN
1
;
Wenshuo ZHENG
1
;
Ziyan GAO
1
;
Yuxin GAN
2
;
Hua LI
3
;
Lixia CHEN
4
,
5
Author Information
1. Institute of Structural Pharmacology & TCM Chemical Biology, Fujian Key Laboratory of Chinese Materia Medica, College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
2. Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
3. Institute of Structural Pharmacology & TCM Chemical Biology, Fujian Key Laboratory of Chinese Materia Medica, College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China. Electronic address: lihua@fjtcm.edu.cn.
4. Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: syzyclx@
5. com.
- Publication Type:Journal Article
- Keywords:
Antioxidant activity;
Daphnanes;
Euphorbia wallichii;
Rhamnofolanes;
Tiglianes
- MeSH:
Euphorbia/chemistry*;
Antioxidants/isolation & purification*;
Diterpenes/isolation & purification*;
Molecular Structure;
Mice;
Molecular Docking Simulation;
Animals;
Hydrogen Peroxide/toxicity*;
Cell Line;
Microglia/drug effects*
- From:
Chinese Journal of Natural Medicines (English Ed.)
2025;23(10):1248-1258
- CountryChina
- Language:English
-
Abstract:
Thirteen novel diterpenoids, comprising seven tiglianes (walliglianes G-M, 1-7), four rhamnofolanes (wallinofolanes A-D, 8-11), and two daphnanes (wallaphnanes A and B, 12 and 13), together with two known rhamnofolane diterpenoids (euphorwallside H and euphorwallside I, 14 and 15), were isolated and characterized from Euphorbia wallichii(E. wallichii). The chemical structures of these compounds were elucidated through nuclear magnetic resonance (NMR), mass spectrometry (MS), and quantum chemical calculations. Compounds 9 and 11 demonstrated protective effects against H2O2-induced BV-2 microglial cell damage. Molecular docking analyses indicated that compound 9 exhibited binding affinity to the anti-oxidant-related targets HMGCR, GSTP1, and SHBG.
