(+)-Strebloside induces Non-Hodgkin lymphoma cell death through the STEAP3-Mediated Ferroptosis and MAPK pathway.
10.1016/S1875-5364(25)60873-9
- Author:
Yu ZHAO
1
;
Jing CAI
1
;
Ying YANG
1
;
Dongmei ZHANG
1
;
Jiayi REN
1
;
Shuyun XIAO
1
;
Jian XU
1
;
Feng FENG
2
;
Rong WU
3
;
Jie ZHANG
4
Author Information
1. School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
2. School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China; School of Pharmacy, Nanjing Medical University, Nanjing 211198, China.
3. Chongqing Wanzhou Food and Drug Inspection Institute, Chongqing Key Laboratory of Development and Utilization of Genuine Medicinal Materials in the Three Gorges Reservoir Area, Chongqing 404100, China. Electronic address: 185634082@qq.com.
4. School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address: 1020152495@cpu.edu.cn.
- Publication Type:Journal Article
- Keywords:
(+)-Strebloside;
Antitumor activity;
Ferroptosis;
MAPK;
Non-Hodgkin lymphoma
- MeSH:
Humans;
Ferroptosis/drug effects*;
Lymphoma, Non-Hodgkin/physiopathology*;
Cell Line, Tumor;
MAP Kinase Signaling System/drug effects*;
Animals;
Cell Proliferation/drug effects*;
Mice;
Apoptosis/drug effects*;
Membrane Proteins/genetics*;
Xenograft Model Antitumor Assays;
Male;
Mice, Nude
- From:
Chinese Journal of Natural Medicines (English Ed.)
2025;23(10):1221-1231
- CountryChina
- Language:English
-
Abstract:
(+)-Strebloside, a significant bioactive compound isolated from the roots of Streblus asper Lour., demonstrates inhibitory effects against multiple malignancies. However, its specific function and underlying mechanistic pathways in Non-Hodgkin lymphoma (NHL) remain unexplored. This investigation sought to elucidate the role and potential mechanisms of (+)-strebloside-induced NHL cell death. The results demonstrated that (+)-strebloside significantly induced apoptosis and ferroptosis in NHL cells, including those from Raji cell-derived xenograft models. Mechanistic analyses revealed that (+)-strebloside enhanced six-transmembrane epithelial antigen of prostate 3 (STEAP3)-induced ferroptosis in NHL, and STEAP3 inhibition reduced the proliferation-inhibitory effects of (+)-strebloside. Furthermore, (+)-strebloside suppressed NHL proliferation through the mitogen-activated protein kinase (MAPK) pathway, and extracellular signal-regulated kinase (ERK) inhibition diminished the proliferation-inhibitory activity induced by (+)-strebloside. These findings indicate that (+)-strebloside presents promising therapeutic potential for NHL treatment.
