Anti-inflammatory and hepatoprotective triterpenoids from the traditional Mongolian medicine Gentianopsis barbata.
10.1016/S1875-5364(25)60870-3
- Author:
Huizhen CHENG
1
;
Huan LIU
1
;
Xiaoyu QI
1
;
Yuzhou FAN
1
;
Zhongzhu YUAN
1
;
Yuanliang XU
1
;
Yanchun LIU
2
;
Yan LIU
1
;
Kai GUO
3
;
Shenghong LI
4
Author Information
1. State Key Laboratory of Southwestern Chinese Medicine Resources, and Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
2. State Key Laboratory of Phytochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
3. State Key Laboratory of Southwestern Chinese Medicine Resources, and Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China. Electronic address: guokai@cdutcm.edu.cn.
4. State Key Laboratory of Southwestern Chinese Medicine Resources, and Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. Electronic address: shli@mail.kib.ac.cn.
- Publication Type:Journal Article
- Keywords:
Anti-inflammatory activity;
Gentianaceae;
Gentianopsis barbata;
Hepatoprotective activity;
Triterpenoids
- MeSH:
Triterpenes/isolation & purification*;
Mice;
Anti-Inflammatory Agents/isolation & purification*;
Animals;
Humans;
RAW 264.7 Cells;
Hep G2 Cells;
Interleukin-6/genetics*;
Tumor Necrosis Factor-alpha/genetics*;
Medicine, Mongolian Traditional;
Macrophages/immunology*;
Protective Agents/isolation & purification*;
Liver/drug effects*;
Gentianaceae/chemistry*;
Plant Extracts/chemistry*;
Molecular Structure
- From:
Chinese Journal of Natural Medicines (English Ed.)
2025;23(9):1111-1121
- CountryChina
- Language:English
-
Abstract:
Gentianopsis barbata (G. barbata) represents a significant plant species with considerable ornamental and medicinal value in China. This investigation sought to elucidate the primary constituents within the plant and investigate their pharmacological properties. Fifty triterpenoids (1-50), including nine previously undescribed compounds (1, 2, 7, 10, 20, 28, 29, 37, and 41) were isolated and characterized from the whole plants of G. barbata. Notably, compounds 1 and 2 exhibited the novel 3,4;9,10-diseco-24-homo-cycloartane triterpenoid skeleton. The isolated triterpenoids demonstrated substantial anti-inflammatory activity through inhibition of tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6) cytokine secretion in LPS-induced RAW264.7 macrophages, and hepatoprotective effects by preventing tert-butyl hydroperoxide (t-BHP)-induced oxidative injury in HepG2 cells. These results demonstrate both the presence of diverse triterpenoids in G. barbata and their therapeutic potential for inflammatory and hepatic conditions, providing scientific evidence supporting the clinical application of this traditional Mongolian medicinal plant.
