Discovery of bioactive polycyclic polyprenylated acylphloroglucinol from Hypericum patulum that protects against hepatic ischemia/reperfusion injury.
10.1016/S1875-5364(25)60975-7
- Author:
Bo TAO
1
;
Xiangli ZHAO
2
;
Zhengyi SHI
3
;
Jie LI
3
;
Yulin DUAN
4
;
Xiaosheng TAN
5
,
6
;
Gang CHEN
7
;
Changxing QI
8
;
Yonghui ZHANG
9
Author Information
1. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
2. Key Laboratory of Organ Transplantation, Ministry of Education; NHC Key Laboratory of Organ Transplantation; Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan 430030, China.
3. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
4. Department of Pharmacy, Wuhan No. 1 Hospital, Wuhan 430022, China.
5. Key Laboratory of Organ Transplantation, Ministry of Education; NHC Key Laboratory of Organ Transplantation; Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan 430030, China. Electronic address: txs900416@
6. com.
7. Key Laboratory of Organ Transplantation, Ministry of Education; NHC Key Laboratory of Organ Transplantation; Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan 430030, China. Electronic address: gchen@tjh.tjmu.edu.cn.
8. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Key Laboratory of Organ Transplantation, Ministry of Education; NHC Key Laboratory of Organ Transplantation; Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan 430030, China. Electronic address: qichangxing@hust.edu.cn.
9. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address: zhangyh@mails.tjmu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Hepatic ischemia/reperfusion injury;
Hypericum patulum;
Natural products;
Polycyclic polyprenylated acylphloroglucinols;
Secondary metabolites
- MeSH:
Reperfusion Injury/prevention & control*;
Animals;
Hypericum/chemistry*;
Phloroglucinol/administration & dosage*;
Mice;
Humans;
Male;
Liver/blood supply*;
Apoptosis/drug effects*;
Molecular Structure;
Protective Agents/pharmacology*;
Hepatocytes/drug effects*;
Mice, Inbred C57BL;
Liver Diseases/drug therapy*
- From:
Chinese Journal of Natural Medicines (English Ed.)
2025;23(9):1104-1110
- CountryChina
- Language:English
-
Abstract:
Hepatic ischemia/reperfusion injury (IRI) remains a critical complication contributing to graft dysfunction following liver surgery. As part of an ongoing search for hepatoprotective natural products, five previously unreported homoadamantane-type polycyclic polyprenylated acylphloroglucinols (PPAPs), named hyperhomanoons A-E (1-5), and one known analog, hypersampsone O (6), were isolated from Hypericum patulum. Among these, compound 6 demonstrated potent protective effects against CoCl₂-induced hypoxic injury in hepatocytes. Furthermore, in a murine model of hepatic IRI induced by vascular occlusion, pretreatment with 6 markedly alleviated liver damage and reduced hepatocyte apoptosis. This study is the first to identify PPAPs as promising scaffolds for the development of therapeutic agents targeting hepatic IRI, underscoring their potential as lead compounds in drug discovery efforts for ischemic liver diseases.
