Diterpenoids and lignans from fossil Chinese medicinal succinum and their activity against renal fibrosis.
10.1016/S1875-5364(25)60916-2
- Author:
Yefei CHEN
1
;
Yunfei WANG
2
;
Yunyun LIU
2
;
Yongming YAN
2
;
Yongxian CHENG
3
Author Information
1. Guangdong Provincial Key Laboratory of Chinese Medicine Ingredients and Gut-Microbiomics, Institute for Inheritance-Based Innovation of Chinese Medicine, Marshall Laboratory of Biomedical Engineering, School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen 518055, China; Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen 518060, China.
2. Guangdong Provincial Key Laboratory of Chinese Medicine Ingredients and Gut-Microbiomics, Institute for Inheritance-Based Innovation of Chinese Medicine, Marshall Laboratory of Biomedical Engineering, School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen 518055, China.
3. Guangdong Provincial Key Laboratory of Chinese Medicine Ingredients and Gut-Microbiomics, Institute for Inheritance-Based Innovation of Chinese Medicine, Marshall Laboratory of Biomedical Engineering, School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen 518055, China; Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen 518060, China. Electronic address: yxcheng@szu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Diterpenoid;
Lignan;
Renal fibrosis;
Succinum
- MeSH:
Animals;
Rats;
Lignans/isolation & purification*;
Diterpenes/isolation & purification*;
Fibrosis/drug therapy*;
Drugs, Chinese Herbal/pharmacology*;
Molecular Structure;
Cell Line;
Kidney Diseases/pathology*;
Transforming Growth Factor beta1/genetics*;
Kidney/metabolism*;
Actins/genetics*;
Fibronectins/genetics*;
Collagen Type I/genetics*;
Epithelial Cells/metabolism*
- From:
Chinese Journal of Natural Medicines (English Ed.)
2025;23(7):888-896
- CountryChina
- Language:English
-
Abstract:
Five previously undescribed diterpenoids, named succipenoids D‒H (1‒5), along with four undescribed lignans, named succignans A‒D (6‒9), were isolated from the dichloromethane extract of Chinese medicinal succinum. Compounds 1‒5 were characterized as nor-abietane diterpenoids, while compounds 6‒9 were identified as lignans polymerized from two groups of phenylpropanoid units. The structures of these novel compounds, including their absolute configurations, were determined through spectroscopic and computational methods. Biological assessments of renal fibrosis demonstrated that compounds 6 and 7 effectively reduce the expression of proteins associated with renal fibrosis, including α-smooth muscle actin (α-SMA), collagen I, and fibronectin in transforming growth factor-β1 (TGF-β1) induced normal rat kidney proximal tubular epithelial cells (NRK-52e).
