Five new meroterpenoids from Rhododendron anthopogonoides and their anti-inflammatory activity.
10.1016/S1875-5364(25)60850-8
- Author:
Mengtian LI
1
;
Norbu KELSANG
2
;
Yongqin ZHAO
1
;
Wensen LI
1
;
Feng ZHOU
2
;
PEMA
2
;
Lu CUI
3
;
Xianjie BAO
3
;
Qian WANG
4
;
Xin FENG
5
,
6
;
Minghua YANG
6
,
7
Author Information
1. State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
2. Tibet Ganlu Pharmaceutical Technology Company, Lhasa 850032, China; Technological Innovation Center of Traditional Tibetan Medicine Modernization of Tibet Autonomous Region, Lhasa 850032, China.
3. Beijing Hospital of Tibetan Medicine, China Tibetology Research Center, Beijing 100029, China.
4. Tibetan Medicine Institute, China Tibetology Research Center China, Beijing 100101, China.
5. Beijing Hospital of Tibetan Medicine, China Tibetology Research Center, Beijing 100029, China; Tibetan Medicine Institute, China Tibetology Research Center China, Beijing 100101, China. Electronic address: fengxin0303@
6. com.
7. State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address: skeepjack@
- Publication Type:Journal Article
- Keywords:
Anti-inflammatory;
Isolation and identification;
Natural products;
Rhododendron athopogonosides Maxim;
Tibetan medicine
- MeSH:
Mice;
Rhododendron/chemistry*;
Animals;
Anti-Inflammatory Agents/isolation & purification*;
RAW 264.7 Cells;
Terpenes/isolation & purification*;
Molecular Structure;
Tumor Necrosis Factor-alpha/immunology*;
Cyclooxygenase 2/immunology*;
Nitric Oxide Synthase Type II/immunology*;
Macrophages/immunology*;
Interleukin-6/immunology*;
Lipopolysaccharides;
Interleukin-1beta/immunology*
- From:
Chinese Journal of Natural Medicines (English Ed.)
2025;23(7):881-887
- CountryChina
- Language:English
-
Abstract:
Five meroterpenoids, rhodonoids K-M (1-2), daurichromene E (3), and grifolins A-B (4-5), together with seven known compounds (6-12), were isolated from Rhododendron anthopogonoides. The chemical structures of these compounds were elucidated through comprehensive analysis of high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), ultraviolet (UV), infrared spectroscopy (IR), and nuclear magnetic resonance (NMR) data. Their absolute configurations were determined by comparing experimental electronic circular dichroism (ECD) spectra with computed values. Notably, compounds 1 and 3 demonstrated significant inhibitory effects on lipopolysaccharide (LPS)-induced inflammation in RAW264.7 cells. These compounds markedly suppressed the mRNA expressions of inflammatory factors, including interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α) while also down-regulating the protein expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).
