The role of 8-OxoG and its repair systems in liver diseases progression: responsible mechanisms and promising natural products.
10.1016/S1875-5364(25)60848-X
- Author:
Ying ZHENG
1
;
Junxin CHEN
1
;
Ze LIU
1
;
Kaibo WANG
1
;
Hao ZHANG
2
Author Information
1. State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
2. State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address: zhanghao@cpu.edu.cn.
- Publication Type:Review
- Keywords:
8-OxoG;
Liver disease;
Natural medicine;
Oxidative stress;
Repair mechanism
- MeSH:
Humans;
Liver Diseases/genetics*;
Biological Products/pharmacology*;
DNA Repair/drug effects*;
Guanine/metabolism*;
Animals;
Disease Progression;
DNA Damage;
Oxidative Stress
- From:
Chinese Journal of Natural Medicines (English Ed.)
2025;23(7):815-823
- CountryChina
- Language:English
-
Abstract:
The accumulation of deoxyribonucleic acid (DNA) oxidative damage mediated by reactive oxygen species (ROS) is closely associated with liver diseases. 8-Oxoguanine (8-OxoG), a prevalent DNA oxidation product, plays a significant role in liver disease progression. The base excision repair (BER) pathway, comprising over 30 proteins including 8-OxoG DNA glycosylase1 (OGG1), MutY homolog (MUTYH), and MutT homolog protein 1 (MTH1), is responsible for the clearance and mismatch repair of 8-OxoG. Abnormally high levels of 8-OxoG and dysregulated expression and function of 8-OxoG repair enzymes contribute to the onset and development of liver diseases. Consequently, targeting the 8-OxoG production and repair system with agonists or inhibitors may offer a promising approach to liver disease treatment. This review summarizes the impact of 8-OxoG accumulation and dysregulated repair enzymes on various liver diseases, including viral liver disease, alcoholic liver disease (ALD), metabolic dysfunction-associated steatotic liver disease (MASLD), cholestatic liver disease (CLD), liver fibrosis, cirrhosis, and liver cancer. Additionally, we review natural constituents as potential therapeutic agents that regulate 8-OxoG production, repair enzymes, and repair system-related signal pathways in oxidative damage-induced liver diseases.
