Paclitaxel anti-cancer therapeutics: from discovery to clinical use.
10.1016/S1875-5364(25)60833-8
- Author:
Haizheng YU
1
;
Fen LAN
2
;
Yuan ZHUANG
1
;
Qizhang LI
3
;
Lianqing ZHANG
2
;
Hongchang TIAN
4
;
Xiao BU
4
;
Ruibing CHEN
4
;
Yingying GAO
4
;
Zhuo WANG
5
,
6
;
Lei ZHANG
7
Author Information
1. Department of Pharmaceutical Botany, School of Pharmacy, Naval Medical University, Shanghai 200433, China; Innovative Drug Research Center, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.
2. Department of Pharmacy, Changhai Hospital, Naval Medical University, Shanghai 200433, China.
3. Innovative Drug R&D Center, College of Life Sciences, Huaibei Normal University, Huaibei 35000, China.
4. Department of Pharmaceutical Botany, School of Pharmacy, Naval Medical University, Shanghai 200433, China.
5. Department of Pharmacy, Changhai Hospital, Naval Medical University, Shanghai 200433, China. Electronic address: wztgyx223@
6. com.
7. Department of Pharmaceutical Botany, School of Pharmacy, Naval Medical University, Shanghai 200433, China; Innovative Drug R&D Center, College of Life Sciences, Huaibei Normal University, Huaibei 35000, China; Innovative Drug Research Center, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China. Electronic address: idrc@zstu.edu.cn.
- Publication Type:Review
- Keywords:
Anti-cancer;
Chemo-immunotherapy;
Chemotherapeutics;
Drug delivery;
Paclitaxel;
Synthesis
- MeSH:
Humans;
Paclitaxel/pharmacology*;
Antineoplastic Agents, Phytogenic/pharmacology*;
Neoplasms/drug therapy*;
Animals;
Taxus/chemistry*
- From:
Chinese Journal of Natural Medicines (English Ed.)
2025;23(7):769-789
- CountryChina
- Language:English
-
Abstract:
Paclitaxel (PTX), a valuable natural product derived from Taxus species, exhibits remarkable anti-cancer properties. It penetrates nanopores in microtubule walls, interacting with tubulin on the lumen surface and disrupting microtubule dynamics, thereby inducing cytotoxic effects in cancer cells. PTX and its derivatives have gained approval for treating various diseases due to their low toxicity, high efficiency, and broad-spectrum application. The widespread success and expanding applications of PTX have led to increased demand, raising concerns about accessibility. Consequently, researchers globally have focused on developing alternative production methods and applying nanocarriers in PTX delivery systems to enhance bioavailability. This review examines the challenges and advancements in PTX sourcing, production, physicochemical properties, anti-cancer mechanisms, clinical applications, trials, and chemo-immunotherapy. It aims to provide a comprehensive reference for the rational development and effective utilization of PTX.
