Research advances in the treatment of arthritis from natural products (2014-present).
10.1016/S1875-5364(25)60862-4
- Author:
Ruilin WANG
1
;
Cen JI
2
;
Jiayao CHEN
2
;
Xiaohan ZHANG
2
;
Qinghua HU
3
;
Chunxiao LIU
4
,
5
Author Information
1. School of Life Science and Technology, China Pharmaceutical University, Nanjing 211198, China; School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
2. School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
3. School of Life Science and Technology, China Pharmaceutical University, Nanjing 211198, China; School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China. Electronic address: huqh@cpu.edu.cn.
4. School of Life Science and Technology, China Pharmaceutical University, Nanjing 211198, China; School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China. Electronic address: pan.linger@
5. com.
- Publication Type:Review
- Keywords:
Arthritis;
Gouty arthritis;
Natural products;
Osteoarthritis;
Rheumatoid arthritis
- MeSH:
Humans;
Biological Products/therapeutic use*;
Animals;
Arthritis, Rheumatoid/drug therapy*;
Arthritis, Gouty/drug therapy*;
Arthritis/drug therapy*;
Osteoarthritis/drug therapy*
- From:
Chinese Journal of Natural Medicines (English Ed.)
2025;23(5):529-540
- CountryChina
- Language:English
-
Abstract:
Arthritis, encompassing osteoarthritis (OA), rheumatoid arthritis (RA), and gouty arthritis (GA), is a prevalent inflammatory disease that significantly impacts quality of life. Natural products (NPs), derived from animals, plants, marine organisms, and microorganisms, have demonstrated beneficial effects in arthritis treatment both domestically and internationally. These natural compounds offer advantages in drug discovery due to their skeletal diversity, structural complexity, and multi-effect, multi-target, and low-toxicity properties compared to conventional small-molecule medicines. However, unclear mechanisms have hindered the development and clinical application of NPs. This review summarizes recent experimental studies from the past decade on natural medicine for arthritis treatment, emphasizing key NPs with therapeutic effects on OA, RA, and GA. It examines the effects and molecular mechanisms of NPs acting on different cells to treat arthritis. Furthermore, this review provides insights into the future prospects of NP research in this field, which is crucial for advancing NP-based arthritis treatments.
