New acylphloroglucinol-sesquiterpenoid adducts with antiviral activities from Dryopteris atrata.
10.1016/S1875-5364(25)60839-9
- Author:
Jihui ZHANG
1
;
Jinghao WANG
2
;
Wei TANG
1
;
Xi SHEN
3
;
Jinlin CHEN
1
;
Huilin OU
1
;
Qianyi SITU
1
;
Yaolan LI
1
;
Guocai WANG
4
;
Yubo ZHANG
5
,
6
;
Nenghua CHEN
7
Author Information
1. Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China.
2. Department of Pharmacy, The First Affiliated Hospital, Jinan University, Guangzhou 510630, China; The Guangzhou Key Laboratory of Basic and Translational Research on Chronic Diseases, Jinan University, Guangzhou 510630, China.
3. Guangdong Clinical Translational Center for Targeted Drug, Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, China.
4. Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China; The Guangzhou Key Laboratory of Basic and Translational Research on Chronic Diseases, Jinan University, Guangzhou 510630, China. Electronic address: twangguocai@jnu.edu.cn.
5. The Guangzhou Key Laboratory of Basic and Translational Research on Chronic Diseases, Jinan University, Guangzhou 510630, China; Guangdong Clinical Translational Center for Targeted Drug, Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, China. Electronic address: ybzhang99@
6. com.
7. Department of Pharmacy, The First Affiliated Hospital, Jinan University, Guangzhou 510630, China; The Guangzhou Key Laboratory of Basic and Translational Research on Chronic Diseases, Jinan University, Guangzhou 510630, China. Electronic address: chennenghua@jnu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Acylphloroglucinol-sesquiterpenoid adducts;
Antiviral activities;
Dryopteris atrata;
Structural elucidation
- MeSH:
Antiviral Agents/isolation & purification*;
Phloroglucinol/isolation & purification*;
Sesquiterpenes/isolation & purification*;
Molecular Structure;
Dryopteris/chemistry*;
Respiratory Syncytial Viruses/drug effects*;
Humans;
Rhizome/chemistry*;
Drugs, Chinese Herbal/pharmacology*
- From:
Chinese Journal of Natural Medicines (English Ed.)
2025;23(3):377-384
- CountryChina
- Language:English
-
Abstract:
Seven novel acylphloroglucinol-sesquiterpenoid adducts, designated as dryatraols J-P (1-7), were isolated from the rhizomes of Dryopteris atrata (Wall. ex Kunze) Ching. The structures, including absolute configurations, were elucidated using comprehensive spectroscopic data, calculated 13C Nuclear Magnetic Resonance-Diastereotopic Probability Assignment Plus (13C NMR-DP4+) probability analysis, and ECD calculations. These structures represent a rare subclass of carbon skeleton of acylphloroglucinol-sesquiterpenoid adducts with a furan ring connecting the acylphloroglucinol and sesquiterpenoid moieties. Notably, compounds 1-6 are the first reported examples of acylphloroglucinol-sesquiterpenoid adducts with dimeric acylphloroglucinol incorporated into the aristolane- or rulepidanol-type sesquiterpene, while compound 7 features a hydroxylated monomeric acylphloroglucinol motif. A preliminary evaluation of their antiviral activities revealed that compounds 1-6 exhibited more potent activities against respiratory syncytial virus (RSV) with IC50 values ranging from 0.75 to 3.12 μmol·L-1 compared to the positive control (ribavirin).
