A quinolinyl analog of resveratrol improves neuronal damage after ischemic stroke by promoting Parkin-mediated mitophagy.
10.1016/S1875-5364(25)60825-9
- Author:
Qingqi MENG
1
;
Yan MI
1
;
Libin XU
1
;
Yeshu LIU
1
;
Dong LIANG
2
;
Yongping WANG
1
;
Yan WANG
2
;
Yueyang LIU
3
,
4
;
Guoliang CHEN
5
;
Yue HOU
6
Author Information
1. Key Laboratory of Bioresource Research and Development of Liaoning Province, College of Life and Health Sciences, National Frontiers Science Center for Industrial Intelligence and Systems Optimization, Key Laboratory of Data Analytics and Optimization for Smart Industry, Ministry of Education, Northeastern University, Shenyang 110167, China.
2. State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China.
3. Shenyang Key Laboratory of Vascular Biology, Science and Research Center, Department of Pharmacology, Shenyang Medical College, Shenyang 110034, China. Electronic address: yueyangliu1989@
4. com.
5. Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: chenguoliang@syphu.edu.cn.
6. Key Laboratory of Bioresource Research and Development of Liaoning Province, College of Life and Health Sciences, National Frontiers Science Center for Industrial Intelligence and Systems Optimization, Key Laboratory of Data Analytics and Optimization for Smart Industry, Ministry of Education, Northeastern University, Shenyang 110167, China. Electronic address: houyue@mail.neu.edu.cn.
- Publication Type:Journal Article
- Keywords:
(E)-4-(3,5-dimethoxystyryl) quinoline;
Ischemic stroke;
Mitophagy;
Parkin;
Resveratrol
- MeSH:
Animals;
Ubiquitin-Protein Ligases/genetics*;
Mitophagy/drug effects*;
Resveratrol/analogs & derivatives*;
Neuroprotective Agents/pharmacology*;
Humans;
Neurons/metabolism*;
Reactive Oxygen Species/metabolism*;
Ischemic Stroke/genetics*;
Male;
Quinolines/pharmacology*;
Mice;
Fallopia japonica/chemistry*;
Mitochondria/metabolism*;
Reperfusion Injury/metabolism*;
Rats;
Mice, Inbred C57BL;
Disease Models, Animal
- From:
Chinese Journal of Natural Medicines (English Ed.)
2025;23(2):214-224
- CountryChina
- Language:English
-
Abstract:
Ischemic stroke (IS) is a prevalent neurological disorder often resulting in significant disability or mortality. Resveratrol, extracted from Polygonum cuspidatum Sieb. et Zucc. (commonly known as Japanese knotweed), has been recognized for its potent neuroprotective properties. However, the neuroprotective efficacy of its derivative, (E)-4-(3,5-dimethoxystyryl) quinoline (RV02), against ischemic stroke remains inadequately explored. This study aimed to evaluate the protective effects of RV02 on neuronal ischemia-reperfusion injury both in vitro and in vivo. The research utilized an animal model of middle cerebral artery occlusion/reperfusion and SH-SY5Y cells subjected to oxygen-glucose deprivation and reperfusion to simulate ischemic conditions. The findings demonstrate that RV02 attenuates neuronal mitochondrial damage and scavenges reactive oxygen species (ROS) through mitophagy activation. Furthermore, Parkin knockdown was found to abolish RV02's ability to activate mitophagy and neuroprotection in vitro. These results suggest that RV02 shows promise as a neuroprotective agent, with the activation of Parkin-mediated mitophagy potentially serving as the primary mechanism underlying its neuroprotective effects.
