Recent advances, strategies, and future perspectives of peptide-based drugs in clinical applications.
10.1016/S1875-5364(25)60800-4
- Author:
Qimeng YANG
1
;
Zhipeng HU
1
;
Hongyu JIANG
1
;
Jialing WANG
1
;
Han HAN
2
,
3
;
Wei SHI
4
;
Hai QIAN
3
,
5
Author Information
1. Centre of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
2. Centre of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. Electronic address: hhan_cpu2017@
3. com.
4. Centre of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. Electronic address: shiwei@cpu.edu.cn.
5. Centre of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China; Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, China Pharmaceutical University, Nanjing 210009, China. Electronic address: qianhai24@
- Publication Type:Review
- Keywords:
Antimicrobial peptides;
Diabetes;
Neurodegenerative diseases;
Oncology;
Peptide-based drugs
- MeSH:
Humans;
Peptides/pharmacology*;
Animals;
Neoplasms/drug therapy*;
Drug Discovery;
Neurodegenerative Diseases/drug therapy*;
Diabetes Mellitus/drug therapy*
- From:
Chinese Journal of Natural Medicines (English Ed.)
2025;23(1):31-42
- CountryChina
- Language:English
-
Abstract:
Peptide-based therapies have attracted considerable interest in the treatment of cancer, diabetes, bacterial infections, and neurodegenerative diseases due to their promising therapeutic properties and enhanced safety profiles. This review provides a comprehensive overview of the major trends in peptide drug discovery and development, emphasizing preclinical strategies aimed at improving peptide stability, specificity, and pharmacokinetic properties. It assesses the current applications and challenges of peptide-based drugs in these diseases, illustrating the pharmaceutical areas where peptide-based drugs demonstrate significant potential. Furthermore, this review analyzes the obstacles that must be overcome in the future, aiming to provide valuable insights and references for the continued advancement of peptide-based drugs.
