Active herbal ingredients and drug delivery design for tumor therapy: a review.
10.1016/S1875-5364(24)60741-7
- Author:
Jing HAN
1
;
Yanxi SHEN
2
;
Ruiying CAO
2
;
Weiren WANG
1
;
Jinao DUAN
1
;
Jialun DUAN
3
;
Chunjie BAO
4
Author Information
1. National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Jiangsu Province Key Laboratory of High Technology Research, Nanjing University of Chinese Medicine, Nanjing 210023, China.
2. School of Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.
3. National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Jiangsu Province Key Laboratory of High Technology Research, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address: jialun.duan@njucm.edu.cn.
4. National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Jiangsu Province Key Laboratory of High Technology Research, Nanjing University of Chinese Medicine, Nanjing 210023, China; School of Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address: chunjie@njucm.edu.cn.
- Publication Type:Review
- Keywords:
Active herbal ingredients;
Anti-tumor therapy;
Smart drug carriers
- MeSH:
Humans;
Neoplasms/drug therapy*;
Drug Delivery Systems;
Drug Carriers/chemistry*;
Animals;
Drugs, Chinese Herbal/therapeutic use*;
Antineoplastic Agents, Phytogenic/administration & dosage*;
Nanoparticles/chemistry*;
Antineoplastic Agents/administration & dosage*
- From:
Chinese Journal of Natural Medicines (English Ed.)
2024;22(12):1134-1162
- CountryChina
- Language:English
-
Abstract:
Active herbal ingredients are gaining recognition for their potent anti-tumor efficacy, attributable to various mechanisms including tumor cell inhibition, immune system activation, and tumor angiogenesis inhibition. Recent studies have revealed that numerous anti-tumor herbal ingredients, such as ginsenosides, ursolic acid, oleanolic acid, and Angelica sinensis polysaccharides, can be utilized to develop smart drug carriers like liposomes, micelles, and nanoparticles. These carriers can deliver active herbal ingredients and co-deliver anti-tumor drugs to enhance drug accumulation at tumor sites, thereby improving anti-tumor efficacy. This study provides a comprehensive analysis of the mechanisms by which these active herbal ingredients-derived carriers enhance therapeutic outcomes. Additionally, it highlights the structural properties of these active herbal ingredients, demonstrating how their unique features can be strategically employed to design smart drug carriers with improved anti-tumor efficacy. The insights presented aim to serve as a reference and guide future innovations in the design and application of smart drug carriers for cancer therapy that leverage active herbal ingredients.
