Glycyrrhizic acid-based multifunctional nanoplatform for tumor microenvironment regulation.
10.1016/S1875-5364(24)60685-0
- Author:
Meng XIAO
1
;
Zhiqing GUO
2
;
Yating YANG
1
;
Chuan HU
1
;
Qian CHENG
1
;
Chen ZHANG
1
;
Yihan WU
1
;
Yanfen CHENG
3
;
Wui Lau Man BENSON
4
;
Sheung Mei Ng SHAMAY
4
;
George Pak-Heng LEUNG
5
;
Jingjing LI
6
,
7
;
Huile GAO
8
;
Jinming ZHANG
9
,
10
Author Information
1. State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy School, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
2. Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China.
3. School of Medicine, Chengdu University, Chengdu 610106, China.
4. Department of Rehabilitation Sciences, Faculty of Health and Social Sciences, Hong Kong Polytechnic University, Hong Kong 999077, China.
5. Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong 999077, China.
6. Department of Rehabilitation Sciences, Faculty of Health and Social Sciences, Hong Kong Polytechnic University, Hong Kong 999077, China; The Research Centre for Chinese Medicine Innovation, Hong Kong Polytechnic University, Hong Kong 999077, China. Electronic address: kim
7. li@polyu.edu.hk.
8. Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China. Electronic address: gaohuile@scu.edu.cn.
9. State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy School, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China. Electronic address: cdutcmzjm@
10. com.
- Publication Type:Review
- Keywords:
Angiogenesis;
Glycyrrhizic acid;
Nanosystem;
Self-assembly;
Tumor microenvironment
- MeSH:
Animals;
Humans;
Antineoplastic Agents/therapeutic use*;
Glycyrrhizic Acid/therapeutic use*;
Liposomes/chemistry*;
Micelles;
Nanoparticles/chemistry*;
Neoplasms/pathology*;
Tumor Microenvironment/drug effects*;
Nanoparticle Drug Delivery System/therapeutic use*
- From:
Chinese Journal of Natural Medicines (English Ed.)
2024;22(12):1089-1099
- CountryChina
- Language:English
-
Abstract:
Natural compounds demonstrate unique therapeutic advantages for cancer treatment, primarily through direct tumor suppression or interference with the tumor microenvironment (TME). Glycyrrhizic acid (GL), a bioactive ingredient derived from the medicinal herb Glycyrrhiza uralensis Fisch., and its sapogenin glycyrrhetinic acid (GA), have been recognized for their ability to inhibit angiogenesis and remodel the TME. Consequently, the combination of GL with other therapeutic agents offers superior therapeutic benefits. Given GL's amphiphilic structure, self-assembly capability, and liver cancer targeting capacity, various GL-based nanoscale drug delivery systems have been developed. These GL-based nanosystems exhibit angiogenesis suppression and TME regulation properties, synergistically enhancing anti-cancer effects. This review summarizes recent advances in GL-based nanosystems, including polymer-drug micelles, drug-drug assembly nanoparticles (NPs), liposomes, and nanogels, for cancer treatment and tumor postoperative care, providing new insights into the anti-cancer potential of natural compounds. Additionally, the review discusses existing challenges and future perspectives for translating GL-based nanosystems from bench to bedside.
