Transdermal delivery of natural products against atopic dermatitis.
10.1016/S1875-5364(24)60681-3
- Author:
Minghui LI
1
;
Yihua XU
2
;
Yanan YU
1
;
Wanshu LI
1
;
Lixia CHEN
1
;
Bo ZHAO
1
;
Yuli GAO
1
;
Jianqing GAO
3
;
Hangjuan LIN
4
,
5
Author Information
1. Department of Pharmacy, Ningbo Municipal Hospital of Traditional Chinese Medicine (TCM), Affiliated Hospital of Zhejiang Chinese Medical University, Ningbo 315010, China.
2. Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
3. Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address: gaojianqing@zju.edu.cn.
4. Department of Pharmacy, Ningbo Municipal Hospital of Traditional Chinese Medicine (TCM), Affiliated Hospital of Zhejiang Chinese Medical University, Ningbo 315010, China. Electronic address: nbszyy_lhj@
5. com.
- Publication Type:Review
- Keywords:
Atopic dermatitis;
Hydrogels;
Microneedles;
Natural products;
Stratum corneum.;
Transdermal drug delivery system
- MeSH:
Animals;
Humans;
Administration, Cutaneous;
Biological Products/pharmacokinetics*;
Dermatitis, Atopic/drug therapy*;
Drug Delivery Systems;
Hydrogels/chemistry*;
Skin/metabolism*;
Skin Absorption
- From:
Chinese Journal of Natural Medicines (English Ed.)
2024;22(12):1076-1088
- CountryChina
- Language:English
-
Abstract:
Atopic dermatitis (AD) is a chronic inflammatory skin condition. Natural products have gained traction in AD treatment due to their accessibility, low toxicity, and favorable pharmacological properties. However, their application is primarily constrained by poor solubility, instability, and limited permeability. The transdermal drug delivery system (TDDS) offers potential solutions for transdermal delivery, enhanced penetration, improved efficacy, and reduced toxicity of natural drugs, aligning with the requirements of modern AD treatment. This review examines the application of hydrogels, microneedles (MNs), liposomes, nanoemulsions, and other TDDS-carrying natural products in AD treatment, with a primary focus on their effects on penetration and accumulation in the skin. The aim is to provide valuable insights into the treatment of AD and other dermatological conditions.
