Advances in the combination of stem cell exosomes with medical devices-the new direction for combination products.
10.1016/S1875-5364(24)60637-0
- Author:
Yuewen ZHAI
1
;
Fang HE
1
;
Ji FANG
1
;
Siwen LI
2
Author Information
1. State Key Laboratory of Natural Medicines, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, Nanjing 211198, China.
2. State Key Laboratory of Natural Medicines, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, Nanjing 211198, China. Electronic address: lsw@cpu.edu.cn.
- Publication Type:Review
- Keywords:
Combination products;
Medical devices;
Stem cell exosomes;
Tissue repair
- MeSH:
Animals;
Humans;
Drug Delivery Systems;
Equipment and Supplies;
Exosomes/metabolism*;
Regenerative Medicine/methods*;
Stem Cells/metabolism*
- From:
Chinese Journal of Natural Medicines (English Ed.)
2024;22(12):1067-1075
- CountryChina
- Language:English
-
Abstract:
Exosomes (exos), nanoscale extracellular vesicles, play a critical role in tissue development and function. Stem cell-derived exos, containing various tissue repair components, show promise as natural therapeutic agents in disease treatment and regenerative medicine. However, challenges persist in their application, particularly in targeted delivery and controlled release, which are crucial for enhancing their biological efficacy. The integration of medical devices may provide a superior platform for improving drug bioavailability. Consequently, the combination products of stem cell-derived exos and medical devices present novel opportunities for expanding the therapeutic potential of exosomes. This review offers a comprehensive overview of the current research frontier in stem cell-derived exos combined with medical devices and discusses the prospective challenges and future prospects in this field.
