Traditional Chinese medicine for treatment of type 2 diabetes mellitus: Clinical evidence and pharmacological mechanisms.
10.1016/j.joim.2025.08.006
- Author:
Hong-Xia NI
1
;
Lin-Hai CAO
1
;
Xiao-Xiao GONG
1
;
Zi-Yan ZANG
1
;
Hui CHANG
2
Author Information
1. College of Food Science, Southwest University, Chongqing 400715, China.
2. College of Food Science, Southwest University, Chongqing 400715, China. Electronic address: changhui2017@swu.edu.cn.
- Publication Type:Review
- Keywords:
Pharmacology;
Traditional Chinese medicine;
Type 2 diabetes mellitus;
microRNAs
- MeSH:
Humans;
Diabetes Mellitus, Type 2/drug therapy*;
Medicine, Chinese Traditional/methods*;
Drugs, Chinese Herbal/pharmacology*;
Hypoglycemic Agents/pharmacology*
- From:
Journal of Integrative Medicine
2025;23(6):605-622
- CountryChina
- Language:English
-
Abstract:
Type 2 diabetes mellitus (T2DM) is a highly prevalent chronic metabolic disease with an increasing incidence worldwide, that poses a significant risk to public health. In many current clinical practices for diabetes management, conventional Western treatments, including oral or injectable hypoglycemic agents, have serious side effects. Given that traditional Chinese medicine (TCM) is characterized by a multi-component, multi-target and multi-pathway approach, its combination with Western medicine could enhance efficacy and reduce adverse effects. Consequently, the use of TCM as a potential auxiliary or alternative treatment for the prevention and/or management of T2DM has emerged as a research hotspot. This article reviews existing reports on TCM in the treatment of T2DM and provides a detailed discussion of its applications. By integrating relevant clinical evidence, this review summarizes the clinical data on 23 TCM formulas and Chinese patent medicines, comprehensively describing their efficacy and potential pharmacological mechanisms in the treatment of T2DM. This includes an exploration of the impacts of TCM-based therapeutic interventions on T2DM-related microRNAs and their target genes. We hope this review not only offers new insights for future research directions but also enhances the understanding of the scientific value of TCM. Please cite this article as: Ni HX, Cao LH, Gong XX, Zang ZY, Chang H. Traditional Chinese medicine for treatment of type 2 diabetes mellitus: Clinical evidence and pharmacological mechanisms. J Integr Med. 2025; 23(6):605-622.
