Research progress on the timing of initiation of renal replacement therapy in patients with sepsis-associated acute kidney injury.

Author: Yating YAN ^{1
,

2} ; He GUO ; Ruimin TAN ; Quansheng DU
Author Information

1. Department of Critical Care Medicine, Hebei General Hospital, Shijiazhuang 050057, China. Corresponding author: Du Quansheng, Email: dqs888@
2. com.
Publication Type:English Abstract
MeSH: Humans; Acute Kidney Injury/etiology*; Renal Replacement Therapy/methods*; Sepsis/therapy*; Time Factors; Intensive Care Units
From: Chinese Critical Care Medicine 2025;37(9):889-892
CountryChina
Language:Chinese
Abstract: Acute kidney injury (AKI) is one of the most common complications in critically ill patients, and sepsis is the main cause of AKI in the intensive care unit (ICU), which can lead to a poor prognosis in severe cases. For patients with sepsis-associated acute kidney injury (SA-AKI) for whom urgent dialysis is indicated, it is now clear that renal replacement therapy (RRT) can be initiated immediately to control disease progression. However, the optimal timing to initiate RRT in patients whose disease is not severe enough to warrant urgent dialysis remains controversial. Some previous studies were small and heterogeneous, and there was a lack of effective reference indicators for guiding RRT in SA-AKI patients. Therefore, this article reviews the relevant experimental studies on the treatment of critically ill patients with AKI in recent years, and reviews the latest research progress on the optimal timing of RRT initiation, in order to provide an effective reference for clinical practice.