Research progress on the role and mechanism of PANoptosis in lung diseases.
10.3760/cma.j.cn121430-20250205-00098
- Author:
Yumei KANG
1
,
2
;
Tao YANG
;
Ling DING
;
Lei WANG
;
Licheng GENG
;
Jiangang XU
Author Information
1. Department of Anesthesiology, Tianjin Union Medical Center (the First Affiliated Hospital of Nankai University), Tianjin 300121, China. Corresponding author: Xu Jiangang, Email: tjyzxet@
2. com.
- Publication Type:English Abstract
- MeSH:
Humans;
Lung Diseases;
Apoptosis;
Pyroptosis;
Pulmonary Disease, Chronic Obstructive;
Necroptosis;
Acute Lung Injury
- From:
Chinese Critical Care Medicine
2025;37(7):688-692
- CountryChina
- Language:Chinese
-
Abstract:
PANoptosis is a newly defined type of programmed cell death (PCD), which is triggered by a variety of stimuli and covers three known forms of PCD: apoptosis, pyroptosis and necroptosis. In physiological state, cell death plays an important protective role against pathogen invasion, but its over-activation may aggravate inflammatory response and cause tissue damage. Studies have shown that the occurrence and progression of acute lung injury/acute respiratory distress syndrome (ALI/ARDS), asthma, chronic obstructive pulmonary disease (COPD) and other lung diseases are closely related to PANoptosis. The purpose of this review is to deeply explore the molecular mechanism of PANoptosis and its regulatory factors in lung diseases, in order to discover potential therapeutic targets and provide new targets and innovative ideas for clinical treatment for lung diseases.
