Research status of experimental animal models of sepsis.
10.3760/cma.j.cn121430-20240226-00162
- Author:
Zhenglin CHANG
1
;
Bingsen CHEN
;
Haojie WU
;
Zhangkai CHENG
;
Baoqing SUN
Author Information
1. Clinical Laboratory Center, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou 510120, Guangdong, China. Corresponding author: Sun Baoqing, Email: sunbaoqing@gzhmu.edu.cn.
- Publication Type:English Abstract
- MeSH:
Sepsis/physiopathology*;
Animals;
Disease Models, Animal;
Humans
- From:
Chinese Critical Care Medicine
2025;37(3):310-316
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is a lethal condition resulting from the host's dysregulated response, involving complex pathophysiological mechanisms, including the host's biphasic immune response and metabolic disturbances. Diagnosing and treating sepsis remain formidable challenges, with the absence of definitive biomarkers and effective therapeutic interventions to date. Animal models of sepsis are pivotal in unraveling the disease's pathogenesis and identifying potential treatments, playing a crucial role in enhancing our comprehension of its intrinsic nature. However, there is no animal model that can comprehensively and accurately simulate the complex pathophysiological process of human sepsis. This review discusses the widely used sepsis animal models, exploring their advantages and limitations in terms of pathogenesis, inflammatory response, pathophysiological changes, and organ dysfunction. It summarizes the application scenarios and latest research advancements of these models and provides an outlook on potential future improvements.
