Progress in the immunometabolism in the regulation of macrophage function in sepsis.
10.3760/cma.j.cn121430-20231216-01089
- Author:
Yingying LU
1
;
Yan BAI
;
Fei LI
;
Zhuqing RAO
Author Information
1. Department of Anesthesiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, China. Corresponding author: Rao Zhuqing, Email: zhuqingrao@njmu.edu.cn.
- Publication Type:English Abstract
- MeSH:
Sepsis/pathology*;
Macrophages/pathology*;
Humans;
Inflammation/pathology*;
Signal Transduction
- From:
Chinese Critical Care Medicine
2024;36(12):1321-1324
- CountryChina
- Language:Chinese
-
Abstract:
Macrophages are widely distributed in peripheral blood, lungs, liver, brain, kidneys, skin, testes, vascular endothelial cells, and other parts of the body. As sentinel cells of innate immunity, they play an important role in the occurrence and development of sepsis. Recent research in immune metabolism has revealed the complicated relationship between specific metabolic pathways of macrophages and their phenotype and function in sepsis. During the pro-inflammatory phase of sepsis, macrophages are characterized by glycolysis, while in the immunosuppressive phase, they rely more on mitochondrial oxidative phosphorylation (OXPHOS). Hence, this review describes how macrophages metabolism related signaling pathways, molecules, enzymes and metabolic intermediates determine their phenotype and function to find critical targets which regulate the body immune status in sepsis.
