Small-molecule probes based on natural products: Elucidation of drug-target mechanisms in stroke.
10.1016/j.jpha.2025.101290
- Author:
Xingyue JIN
1
;
Suyi LIU
1
;
Shujing CHEN
1
;
Rui HAN
1
;
Xingyi SUN
1
;
Mingyan WEI
1
;
Yanxu CHANG
1
;
Lin LI
1
;
Han ZHANG
1
Author Information
1. State Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
- Publication Type:Review
- Keywords:
Labeled probes;
Natural products;
Protein identification;
Small-molecule probes;
Stroke;
Unlabeled probes
- From:
Journal of Pharmaceutical Analysis
2025;15(11):101290-101290
- CountryChina
- Language:English
-
Abstract:
Natural products (NPs) are an important source of new drugs for the treatment of stroke. Identifying cellular targets for bioactive molecules is a major challenge and critical issue in the development of new drugs for stroke. Small-molecule probes play a unique role in target discovery. However, drawbacks to these probes include non-specificity, unstable activity, and difficulty in synthesis. Small-molecule probes based on NPs at least partially compensate for these shortcomings. NPs feature rich chemical and structural diversity, biocompatibility, and unique biological activities. These features could be exploited to provide new ideas and tools for target discovery. Small-molecule probes based on NPs provide a precise and direct search for interacting protein targets of NPs-active small molecules. This review explores the properties of small-molecule probes based on NPs and their applications in mechanistic studies of stroke and other diseases. We hope that this review will bring new perspectives to the mechanistic study of NPs-active small molecules and accelerate the translation of these ingredients into drug candidates for the treatment of stroke.
