Systematic review on the extracellular vesicles in reproductive medicine and gamete union.
10.1016/j.jpha.2025.101261
- Author:
Yutao WANG
1
;
Honghao SUN
2
;
Fangdie YE
3
;
Zhiwei LI
4
;
Zhongru FAN
5
;
Xun FU
1
;
Yi LU
1
;
Jianbin BI
6
;
Hongjun LI
1
Author Information
1. Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100000, China.
2. Center of Reproductive Medicine, Shengjing Hospital of China Medical University, Shenyang, 110000, China.
3. Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, 200000, China.
4. The Second Affiliated Hospital, Department of Urology, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China.
5. Department of Urology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu, 215000, China.
6. Department of Urology, The First Affiliated Hospital of China Medical University, Shenyang, 110000, China.
- Publication Type:Review
- Keywords:
Assisted reproductive technology;
Drug delivery;
Exosomes;
Extracellular vesicles;
Reproductive medicine
- From:
Journal of Pharmaceutical Analysis
2025;15(10):101261-101261
- CountryChina
- Language:English
-
Abstract:
In this comprehensive review, we delve into the evolution of drug delivery systems in reproductive medicine with a focus on the emerging role of exosomes, a class of extracellular vesicles. Exosomes offer unique advantages in overcoming these challenges due to their inherent biocompatibility, stability, and ability to facilitate targeted delivery. This review provides a detailed examination of exosome biogenesis and their function in cellular communication, setting the stage for understanding their potential as drug delivery vehicles. We explore the mechanisms through which exosomes can be loaded with small molecule drugs and the benefits they offer over synthetic nanoparticles. The review highlights groundbreaking case studies that illustrate the successful application of exosome-mediated drug delivery in reproductive health, including enhancing fertility treatments, supporting gamete and embryo development, and facilitating maternal-fetal communication. This study aims to provide a precise understanding of how exosomal drug delivery can revolutionize treatments for reproductive health disorders, paving the way for future therapeutic applications. Lastly, we touch upon the promising therapeutic implications of exosomal delivery for proteins and genes, offering a window into future treatments for reproductive health disorders.
