Isovalerylspiramycin I alleviates liver injury and liver fibrosis by targeting the nucleotide-binding protein 2 (NUBP2)-vascular non-inflammatory molecule-1 (VNN1) pathway.
10.1016/j.jpha.2024.101048
- Author:
Na ZHANG
1
;
Weixiao NIU
2
;
Weiping NIU
1
;
Yiming LI
1
;
Simin GUO
1
;
Yang LI
1
;
Weiqing HE
3
;
Hongwei HE
1
Author Information
1. NHC Key Laboratory of Biotechnology for Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
2. Medical Department of Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, China.
3. CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
- Publication Type:Journal Article
- Keywords:
Carrimycin;
Isovalerylspiramycin I;
Liver fibrosis;
Nucleotide-binding protein 2;
Vascular non-inflammatory molecule-1
- From:
Journal of Pharmaceutical Analysis
2025;15(3):101048-101048
- CountryChina
- Language:English
-
Abstract:
Liver fibrosis is a vital cause of morbidity in patients with liver diseases and developing novel anti-fibrotic drugs is imperative. Isovalerylspiramycin I (ISP I) as a major component of carrimycin applied to upper respiratory infections, was first found to possess anti-fibrotic potential. The present study aims to evaluate the functions and mechanisms of ISP I in protecting against liver fibrosis. According to our results, ISP I not only reduced the expressions of fibrogenic markers in LX-2 cells but also appeared great protective effects on liver injury and liver fibrosis in bile duct ligation (BDL) rats and carbon tetrachloride (CCl4) mice. We proved that nucleotide-binding protein 2 (NUBP2) was the direct target of ISP I. ISP I through targeting NUBP2, increased the amount of vascular non-inflammatory molecule-1 (VNN1) on the cell membrane, which will inhibit oxidative stress and fibrosis. Simultaneously, the original carrimycin's protective effect on liver damage and fibrosis was verified. Therefore, our study provides potential agents for patients with liver fibrosis-related diseases, and the clear mechanism supports wide application in the clinic.
