Targeting AMPK related signaling pathways: A feasible approach for natural herbal medicines to intervene non-alcoholic fatty liver disease.
10.1016/j.jpha.2024.101052
- Author:
Yongqing CAI
1
;
Lu FANG
2
;
Fei CHEN
3
;
Peiling ZHONG
2
;
Xiangru ZHENG
4
;
Haiyan XING
1
;
Rongrong FAN
5
;
Lie YUAN
2
;
Wei PENG
6
;
Xiaoli LI
2
Author Information
1. Department of Pharmacy, Daping Hospital, Army Medical University, Chongqing, 400042, China.
2. Department of Pharmacology, College of Pharmacy, Chongqing Medical University, Chongqing, 400016, China.
3. Department of Pharmacy, Dazhou Integrated Traditional Chinese Medicine and Western Medicine Hospital, Dazhou, Sichuan, 635000, China.
4. Department of Pharmacy, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120, China.
5. Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, 14152, Sweden.
6. School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
- Publication Type:Review
- Keywords:
AMPK signaling;
Autophagy;
Lipid metabolism;
NAFLD;
Natural herbal medicines;
Oxidative stress
- From:
Journal of Pharmaceutical Analysis
2025;15(1):101052-101052
- CountryChina
- Language:English
-
Abstract:
Non-alcoholic fatty liver disease (NAFLD) is a metabolic disease characterized by abnormal deposition of lipid in hepatocytes. If not intervened in time, NAFLD may develop into liver fibrosis or liver cancer, and ultimately threatening life. NAFLD has complicated etiology and pathogenesis, and there are no effective therapeutic means and specific drugs. Currently, insulin sensitizers, lipid-lowering agents and hepatoprotective agents are often used for clinical intervention, but these drugs have obvious side effects, and their effectiveness and safety need to be further confirmed. Adenosine monophosphate (AMP)-activated protein kinase (AMPK) plays a central role in maintaining energy homeostasis. Activated AMPK can enhance lipid degradation, alleviate insulin resistance (IR), suppress oxidative stress and inflammatory response, and regulate autophagy, thereby alleviating NAFLD. Natural herbal medicines have received extensive attention recently because of their regulatory effects on AMPK and low side effects. In this article, we reviewed the biologically active natural herbal medicines (such as natural herbal medicine formulas, extracts, polysaccharides, and monomers) that reported in recent years to treat NAFLD via regulating AMPK, which can serve as a foundation for subsequent development of candidate drugs for NAFLD.
