Application of lipidomics in the study of traditional Chinese medicine.

Yang YANG; Guangyi YANG; Wenpeng ZHANG; Lingyi XIN; Jing ZHU; Hangtian WANG; Baodong FENG; Renyan LIU; Shuya ZHANG; Yuanwu CUI; Qinhua CHEN; Dean GUO

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Application of lipidomics in the study of traditional Chinese medicine.

Author: Yang YANG ¹ ; Guangyi YANG ² ; Wenpeng ZHANG ³ ; Lingyi XIN ¹ ; Jing ZHU ¹ ; Hangtian WANG ² ; Baodong FENG ¹ ; Renyan LIU ¹ ; Shuya ZHANG ¹ ; Yuanwu CUI ¹ ; Qinhua CHEN ¹ ; Dean GUO ⁴
Author Information

1. Key Laboratory of TCM Clinical Pharmacy, Shenzhen Bao'an Authentic TCM Therapy Hospital, Shenzhen, Guangdong, 518000, China.
2. Department of Pharmacy, Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen, Guangdong, 518000, China.
3. State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instrument, Tsinghua University, Beijing, 100084, China.
4. Laboratory for TCM Standardization Technology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Publication Type:Review
Keywords: Curative effect; Lipidomics; Mechanism; Quality control; Toxicity; Traditional Chinese medicine
From: Journal of Pharmaceutical Analysis 2025;15(2):101083-101083
CountryChina
Language:English
Abstract: Lipidomics is an emerging discipline that systematically studies the various types, functions, and metabolic pathways of lipids within living organisms. This field compares changes in diseases or drug impact, identifying biomarkers and molecular mechanisms present in lipid metabolic networks across different physiological or pathological states. Through employing analytical chemistry within the realm of lipidomics, researchers analyze traditional Chinese medicine (TCM). This analysis aids in uncovering potential mechanisms for treating diverse physiopathological conditions, assessing drug efficacy, understanding mechanisms of action and toxicity, and generating innovative ideas for disease prevention and treatment. This manuscript assesses recent literature, summarizing existing lipidomics technologies and their applications in TCM research. It delineates the efficacy, mechanisms, and toxicity research related to lipidomics in Chinese medicine. Additionally, it explores the utilization of lipidomics in quality control research for Chinese medicine, aiming to expand the application of lipidomics within this field. Ultimately, this initiative seeks to foster the integration of traditional medicine theory with modern science and technology, promoting an organic fusion between the two domains.