Exosomal circRNAs: Deciphering the novel drug resistance roles in cancer therapy.
10.1016/j.jpha.2024.101067
- Author:
Xi LI
1
;
Hanzhe LIU
2
;
Peiyu XING
3
;
Tian LI
4
;
Yi FANG
5
;
Shuang CHEN
6
;
Siyuan DONG
7
Author Information
1. Department of Vascular and Thyroid Surgery, The First Hospital of China Medical University, Shenyang, 110001, China.
2. Department of Critical Care Medicine, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, 110042, China.
3. Department of Ophthalmology, China Medical University the Fourth People's Hospital of Shenyang, Shenyang, 110031, China.
4. School of Basic Medicine, The Fourth Military Medical University, Xi'an, 710032, China.
5. Department of Ultrasound, The First Hospital of China Medical University, Shenyang, 110001, China.
6. Department of Cardiology, The First Hospital of China Medical University, Shenyang, 110001, China.
7. Department of Thoracic Surgery, The First Hospital of China Medical University, Shenyang, 110001, China.
- Publication Type:Review
- Keywords:
Cancer biomarkers;
Exosomal circRNAs;
Tumor microenvironment
- From:
Journal of Pharmaceutical Analysis
2025;15(2):101067-101067
- CountryChina
- Language:English
-
Abstract:
Exosomal circular RNA (circRNAs) are pivotal in cancer biology, and tumor pathophysiology. These stable, non-coding RNAs encapsulated in exosomes participated in cancer progression, tumor growth, metastasis, drug sensitivity and the tumor microenvironment (TME). Their presence in bodily fluids positions them as potential non-invasive biomarkers, revealing the molecular dynamics of cancers. Research in exosomal circRNAs is reshaping our understanding of neoplastic intercellular communication. Exploiting the natural properties of exosomes for targeted drug delivery and disrupting circRNA-mediated pro-tumorigenic signaling can develop new treatment modalities. Therefore, ongoing exploration of exosomal circRNAs in cancer research is poised to revolutionize clinical management of cancer. This emerging field offers hope for significant breakthroughs in cancer care. This review underscores the critical role of exosomal circRNAs in cancer biology and drug resistance, highlighting their potential as non-invasive biomarkers and therapeutic targets that could transform the clinical management of cancer.
