Mitochondria and myocardial ischemia/reperfusion injury: Effects of Chinese herbal medicine and the underlying mechanisms.
10.1016/j.jpha.2024.101051
- Author:
Chuxin ZHANG
1
;
Xing CHANG
2
;
Dandan ZHAO
1
;
Yu HE
1
;
Guangtong DONG
1
;
Lin GAO
1
Author Information
1. Beijing University of Chinese Medicine, Beijing, 100029, China.
2. Guang'anmen Hospital of Chinese Academy of Traditional Chinese Medicine, Beijing, 100053, China.
- Publication Type:Review
- Keywords:
Mitochondria;
Mitochondrial quality control;
Myocardial ischemia-reperfusion injury;
Oxidative stress;
Traditional Chinese medicine
- From:
Journal of Pharmaceutical Analysis
2025;15(2):101051-101051
- CountryChina
- Language:English
-
Abstract:
Ischemic heart disease (IHD) is associated with high morbidity and mortality rates. Reperfusion therapy is the best treatment option for this condition. However, reperfusion can aggravate myocardial damage through a phenomenon known as myocardial ischemia/reperfusion (I/R) injury, which has recently gained the attention of researchers. Several studies have shown that Chinese herbal medicines and their natural monomeric components exert therapeutic effects against I/R injury. This review outlines the current knowledge on the pathological mechanisms through which mitochondria participate in I/R injury, focusing on the issues related to energy metabolism, mitochondrial quality control disorders, oxidative stress, and calcium. The mechanisms by which mitochondria mediate cell death have also been discussed. To develop a resource for the prevention and management of clinical myocardial I/R damage, we compiled the most recent research on the effects of Chinese herbal remedies and their monomer components.
