Particulate matter exposure and end-stage renal disease risk in IgA nephropathy.
10.1007/s11684-025-1162-2
- Author:
Yilin CHEN
1
;
Huan ZHOU
1
;
Siqing WANG
1
;
Lingqiu DONG
1
;
Yi TANG
1
;
Wei QIN
2
Author Information
1. Division of Nephrology, Department of Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China.
2. Division of Nephrology, Department of Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China. qinweihx@scu.edu.cn.
- Publication Type:Journal Article
- Keywords:
IgA nephropathy;
PM10;
PM2.5;
air pollution;
end-stage renal disease
- MeSH:
Humans;
Glomerulonephritis, IGA/pathology*;
Particulate Matter/adverse effects*;
Male;
Female;
Kidney Failure, Chronic/epidemiology*;
Adult;
China/epidemiology*;
Disease Progression;
Environmental Exposure/adverse effects*;
Middle Aged;
Proportional Hazards Models;
Risk Factors;
Air Pollutants/adverse effects*;
Cohort Studies
- From:
Frontiers of Medicine
2025;19(5):855-864
- CountryChina
- Language:English
-
Abstract:
Long-term exposure to particulate matter has been increasingly implicated in the progression of chronic kidney disease (CKD). However, its impact on IgA nephropathy (IgAN), a leading cause of end-stage renal disease (ESRD), remains unclear. A total of 1768 IgAN patients, confirmed by renal biopsy were included in this cohort study. Long-term exposure to PM2.5 and PM10 was assessed using high-resolution satellite-based data from the China High Air Pollutants (CHAP) dataset. Cox proportional hazards models were used to estimate the associations between PM2.5 or PM10 and ESRD risk, adjusting for demographic, clinical, and biochemical covariates. Over a median follow-up of 3.63 years, 209 participants progressed to ESRD. Higher exposure to both PM2.5 and PM10 was significantly associated with an increased risk, with hazard ratios of 1.62 and 1.36 per 10 µg/m3 increase, respectively. A nonlinear dose-response relationship was observed, with risk increasing markedly beyond threshold levels. Trajectory modeling of prebaseline exposure identified a subgroup with persistently high and fluctuating particulate matter exposure that showed the highest risk. This study provides strong evidence that prolonged exposure to ambient particulate matter contributes to renal disease progression in individuals with IgAN.
