Global, regional and national burden and trends of congenital musculoskeletal and limb deformities among under-5 children from 1990 to 2021: a systematic analysis for the Global Burden of Disease Study 2021.
10.1007/s11684-025-1156-0
- Author:
Qinglin YANG
1
;
Zhuanmei JIN
1
;
Yongping WANG
2
,
3
Author Information
1. The First Clinical Medical College of Lanzhou University, Lanzhou, 730000, China.
2. Department of Orthopedics, the Second Affiliated Hospital of Hainan Medical University, Haikou, 570311, China. wangyp0312@
3. com.
- Publication Type:Systematic Review
- Keywords:
congenital musculoskeletal and limb deformities;
disability-adjusted life years;
global burden of disease;
incidence;
prevalence;
trend
- MeSH:
Humans;
Global Burden of Disease/trends*;
Child, Preschool;
Global Health/statistics & numerical data*;
Infant;
Male;
Prevalence;
Limb Deformities, Congenital/mortality*;
Musculoskeletal Abnormalities/mortality*;
Female;
Disability-Adjusted Life Years;
Incidence;
Infant, Newborn;
Cost of Illness;
Socioeconomic Factors
- From:
Frontiers of Medicine
2025;19(5):807-819
- CountryChina
- Language:English
-
Abstract:
Congenital musculoskeletal and limb deformities (CMLD) seriously affect the physical and mental health of patients, and pose great challenges to healthcare systems worldwide. We explored the specific situation and changes of incidence, prevalence, disability-adjusted life years rates, and mortality of CMLD in under-5 children from 1990 to 2021 in different groups, including different regions, periods, genders and socio-demographic indices (SDI), through corresponding analytical models. Overall, the global disease burden of CMLD in under-5 children has decreased from 1990 to 2021. The disease burden of CMLD in under-5 children varied significantly among different regions and countries, and there was a strong correlation between the corresponding burden of disease and the level of SDI. In addition, cross-country inequality analysis showed that while absolute inequalities in the disease burden of CMLD in under-5 children have improved, relative inequalities have worsened. It is essential to reduce the global health impact of CMLD by implementing targeted interventions to improve health care in underdeveloped areas.
