Research progress on molecular mechanism and future perspectives of leonurine.
10.1007/s11684-025-1138-2
- Author:
Ran WANG
1
;
Aiying LI
2
;
Zongran PANG
3
Author Information
1. School of Pharmacy, Key Laboratory of Ethnomedicine of Ministry of Education, Minzu University of China, Beijing, 100081, China. rwang@muc.edu.cn.
2. School of Nursing, Hebei University of Chinese Medicine, Shijiazhuang, 050200, China.
3. School of Pharmacy, Key Laboratory of Ethnomedicine of Ministry of Education, Minzu University of China, Beijing, 100081, China. pangzongran@muc.edu.cn.
- Publication Type:Review
- Keywords:
Leonurus japonicas Houtt.;
future perspectives;
leonurine;
molecular mechanism;
research progress
- MeSH:
Humans;
Gallic Acid/therapeutic use*;
Leonurus/chemistry*;
Cardiovascular Diseases/drug therapy*;
Animals;
Central Nervous System Diseases/drug therapy*
- From:
Frontiers of Medicine
2025;19(4):612-625
- CountryChina
- Language:English
-
Abstract:
Leonurus japonicas Houtt., has been recorded as "light body and long life" properties in the oldest classical medicinal book Shennong Bencao Jing thousands of years ago. Herba leonuri, also named Chinese Motherwort or Siberian Motherwort, has the effects of activating blood circulation, regulating menstruation, diuresis and detumescence, clearing heat and detoxifying, and is known as the "sacred medicine of gynecology." It has been well known by doctors and usually used in the treatment of common gynecological diseases in clinic. Leonurine is a very important alkaloid in Herba leonuri, which has many biological activities such as anti-oxidation, anti-inflammation, and anti-apoptosis. Diseases of the cardiovascular system and central nervous system are "major health threats" that threaten human life and health worldwide, however, many drugs have certain side effects right now. This paper reviews the potential molecular therapeutic effects of leonurine on cardiovascular system and central nervous system diseases, highlights the current findings of research progress, and focuses on the therapeutic effects of leonurine in various diseases. At present, leonurine is in the stage of clinical experiment, and we hope that our summary can provide guidance for its future molecular mechanism study and clinical application.
