Metabolism and metabolomics in senescence, aging, and age-related diseases: a multiscale perspective.
10.1007/s11684-024-1116-0
- Author:
Ziyi WANG
1
;
Hongying ZHU
2
;
Wei XIONG
3
Author Information
1. Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China.
2. Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China. zhuhy62@ustc.edu.cn.
3. Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China. wxiong@ustc.edu.cn.
- Publication Type:Review
- Keywords:
age-related diseases;
aging;
metabolism;
metabolomics;
senescence
- MeSH:
Humans;
Aging/metabolism*;
Metabolomics/methods*;
Neurodegenerative Diseases/metabolism*;
Cardiovascular Diseases/metabolism*
- From:
Frontiers of Medicine
2025;19(2):200-225
- CountryChina
- Language:English
-
Abstract:
The pursuit of healthy aging has long rendered aging and senescence captivating. Age-related ailments, such as cardiovascular diseases, diabetes, and neurodegenerative disorders, pose significant threats to individuals. Recent studies have shed light on the intricate mechanisms encompassing genetics, epigenetics, transcriptomics, and metabolomics in the processes of senescence and aging, as well as the establishment of age-related pathologies. Amidst these underlying mechanisms governing aging and related pathology metabolism assumes a pivotal role that holds promise for intervention and therapeutics. The advancements in metabolomics techniques and analysis methods have significantly propelled the study of senescence and aging, particularly with the aid of multiscale metabolomics which has facilitated the discovery of metabolic markers and therapeutic potentials. This review provides an overview of senescence and aging, emphasizing the crucial role metabolism plays in the aging process as well as age-related diseases.
