Novel perspectives on the link between obesity and cancer risk: from mechanisms to clinical implications.
10.1007/s11684-024-1094-2
- Author:
Xiaoye SHI
1
;
Aimin JIANG
2
;
Zhengang QIU
3
;
Anqi LIN
1
;
Zaoqu LIU
4
;
Lingxuan ZHU
1
;
Weiming MOU
1
;
Quan CHENG
5
;
Jian ZHANG
6
;
Kai MIAO
7
;
Peng LUO
8
Author Information
1. Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
2. Department of Urology, Changhai Hospital, Naval Medical University (Second Military Medical University), Shanghai, 200433, China.
3. Department of Neurology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, China.
4. Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, China.
5. Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, 410008, China. chengquan@csu.edu.cn.
6. Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China. zhangjian@i.smu.edu.cn.
7. Cancer Centre, Faculty of Health Sciences, University of Macau, Macao SAR, 999078, China. kaimiao@um.edu.mo.
8. Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China. luopeng@smu.edu.cn.
- Publication Type:Review
- Keywords:
cancer prevention;
cancer risk;
carcinogenesis;
obesity;
obesity-associated cancers
- MeSH:
Humans;
Adipokines/metabolism*;
Bariatric Surgery;
Inflammation/therapy*;
Neoplasms/prevention & control*;
Obesity/therapy*;
Risk Factors
- From:
Frontiers of Medicine
2024;18(6):945-968
- CountryChina
- Language:English
-
Abstract:
Existing epidemiologic and clinical studies have demonstrated that obesity is associated with the risk of a variety of cancers. In recent years, an increasing number of experimental and clinical studies have unraveled the complex relationship between obesity and cancer risk and the underlying mechanisms. Obesity-induced abnormalities in immunity and biochemical metabolism, including chronic inflammation, hormonal disorders, dysregulation of adipokines, and microbial dysbiosis, may be important contributors to cancer development and progression. These contributors play different roles in cancer development and progression at different sites. Lifestyle changes, weight loss medications, and bariatric surgery are key approaches for weight-centered, obesity-related cancer prevention. Treatment of obesity-related inflammation and hormonal or metabolic dysregulation with medications has also shown promise in preventing obesity-related cancers. In this review, we summarize the mechanisms through which obesity affects the risk of cancer at different sites and explore intervention strategies for the prevention of obesity-associated cancers, concluding with unresolved questions and future directions regarding the link between obesity and cancer. The aim is to provide valuable theoretical foundations and insights for the in-depth exploration of the complex relationship between obesity and cancer risk and its clinical applications.
