Western Pacific Region Index Medicus

An upgraded nuclease prime editor platform enables high-efficiency singled or multiplexed knock-in/knockout of genes in mouse and sheep zygotes.

Author: Weijia MAO ¹ ; Pei WANG ² ; Lei ZHOU ¹ ; Dongxu LI ¹ ; Xiangyang LI ³ ; Xin LOU ⁴ ; Xingxu HUANG ³ ; Feng WANG ¹ ; Yanli ZHANG ¹ ; Jianghuai LIU ² ; Yongjie WAN ¹
Author Information

1. Livestock Embryo Engineering Laboratory, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
2. State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center at Medical School of Nanjing University, Nanjing 210061, China.
3. The Key Laboratory of Pancreatic Diseases of Zhejiang Province, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
4. Zhejiang Laboratory, Hangzhou 311121, China.
Publication Type:Journal Article
From: Protein & Cell 2025;16(8):732-738
CountryChina
Language:English