Stress granules and organelles: coordinating cellular responses in health and disease.

Author: Ying LIU ¹ ; Yin LI ¹ ; Peipei ZHANG ¹
Author Information

1. Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China.
Publication Type:Review
Keywords: interplay; membraneless organelle; organelles; stress granules; techniques
MeSH: Humans; Stress Granules/pathology*; Organelles/metabolism*; Amyotrophic Lateral Sclerosis/pathology*; Animals; Stress, Physiological; Cytoplasmic Granules/metabolism*
From: Protein & Cell 2025;16(6):418-438
CountryChina
Language:English
Abstract: Membrane-bound organelles and membraneless organelles (MLOs) coordinate various biological processes within eukaryotic cells. Among these, stress granules (SGs) are significant cytoplasmic MLOs that form in response to cellular stress, exhibiting liquid-like properties alongside stable substructures. SGs interact with diverse organelles, thereby influencing cellular pathways that are critical in both health and disease contexts. This review discusses the interplay between SGs and organelles and explores the methodologies employed to analyze interactions between SGs and other MLOs. Furthermore, it highlights the pivotal roles SGs play in regulating cellular responses and the pathogenesis of amyotrophic lateral sclerosis. Gaining insights into these interactions is essential for deciphering the mechanisms underlying both physiological processes and pathological conditions.