Natural polyphenols as novel interventions for aging and age-related diseases: Exploring efficacy, mechanisms of action and implications for future research.
10.1016/j.chmed.2024.09.001
- Author:
Wenze WU
1
;
Yan MI
1
;
Qingqi MENG
1
;
Ning LI
2
;
Wei LI
3
;
Pu WANG
4
;
Yue HOU
1
Author Information
1. Liaoning Key Laboratory of Bioresource Research and Development, National Frontiers Science Center for Industrial Intelligence and Systems Optimization, Key Laboratory of Data Analytics and Optimization for Smart Industry, Ministry of Education, College of Life and Health Sciences, Northeastern University, Shenyang 110169, China.
2. Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 117004, China.
3. Faculty of Pharmaceutical Sciences, Toho University, Miyama, Funabashi, Chiba 274-8510, Japan.
4. College of Pharmacy, Shenzhen Technology University, Shenzhen 518118, China.
- Publication Type:Review
- Keywords:
aging;
cancer;
cardiovascular disease;
natural polyphenols;
neurodegenerative diseases
- From:
Chinese Herbal Medicines
2025;17(2):279-291
- CountryChina
- Language:English
-
Abstract:
Natural polyphenols are a group of components widely found in traditional Chinese medicines and have been demonstrated to delay or prevent the development of aging and age-related diseases in recent years. As far as we know, the studies of natural polyphenols in aging and aging-related diseases have never been extensively reviewed. In the present paper, we reviewed recent advances of natural polyphenols in aging and common age-related diseases and the current technological methods to improve the bioavailability of natural polyphenols. The results showed that natural polyphenols have the potential to prevent or treat aging and common age-related diseases through multiple mechanisms. Nanotechnology, structural modifications, and matrix processing could provide strong technical support for the development of natural polyphenols to prevent or treat aging and age-related diseases. In conclusion, natural polyphenols have important potential in the prevention and treatment of aging and age-related diseases.
