A systematical review on traditional Chinese medicine treating chronic diseases via regulating ferroptosis from the perspective of experimental evidence and clinical application.
10.1016/j.chmed.2025.01.003
- Author:
Yuanyuan ZHANG
1
;
Fazhi SU
1
;
Enlin ZHU
2
;
Yanping SUN
1
;
Haixue KUANG
1
;
Qiuhong WANG
1
Author Information
1. Key Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
2. Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
- Publication Type:Review
- Keywords:
chronic metabolic diseases;
diabetes mellitus;
ferroptosis;
hyperlipidemia;
hypertension;
traditional Chinese medicine
- From:
Chinese Herbal Medicines
2025;17(2):246-260
- CountryChina
- Language:English
-
Abstract:
Ferroptosis is a unique regulated form of cell death that is distinct from apoptosis, necrosis, and other well-characterized regulated cell death types, and plays an important role in the occurrence and development of chronic metabolic diseases, including diabetes, hypertension, hyperlipidemia, and non-alcoholic steatohepatitis. Recently, increasing evidence has supported traditional Chinese medicine (TCM) as a new hot spot for the treatment of chronic metabolic diseases by mediating ferroptosis. Unfortunately, few systematic reviews have described the importance of TCM in treating chronic metabolic diseases through the ferroptosis pathway. In the current review, the mechanism of ferroptosis and the roles of ferroptosis in chronic metabolic diseases are summarized. Additionally, this review illustrates that the regulation of ferroptosis by TCM could be an effective approach for treating chronic metabolic diseases based on experimental evidence and clinical application. In summary, this work will improve the understanding of ferroptosis and the ability of TCM to regulate ferroptosis in chronic metabolic diseases, thereby promoting the development and application of natural TCM.
