An injectable bioceramics-containing composite hydrogel promoting innervation for pulp-dentin complex repair.
10.1038/s41368-025-00398-0
- Author:
Xingyu TAO
1
;
Hongjian ZHANG
1
;
Peng MEI
2
;
Jinzhou HUANG
1
;
Bing FANG
2
;
Zhiguang HUAN
3
;
Chengtie WU
4
Author Information
1. State Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, China.
2. Department of Orthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai, China.
3. State Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, China. huanzhiguang@mail.sic.ac.cn.
4. State Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, China. chengtiewu@mail.sic.ac.cn.
- Publication Type:Journal Article
- MeSH:
Dental Pulp/drug effects*;
Hydrogels/pharmacology*;
Animals;
Ceramics/pharmacology*;
Dentin/drug effects*;
Biocompatible Materials/pharmacology*;
Rats;
Gelatin;
Regeneration/drug effects*;
Cell Differentiation/drug effects*;
Injections;
Humans;
Odontogenesis/drug effects*
- From:
International Journal of Oral Science
2025;17(1):66-66
- CountryChina
- Language:English
-
Abstract:
Dental pulp-dentin complex defects remain a major unresolved problem in oral medicines. Clinical therapeutic methods including root canal therapy and vital pulp therapy are both considered as conservative strategies, which are incapable of repairing the pulp-dentin complex defects. Although biomaterial-based strategies show remarkable progress in antibacterial, anti-inflammatory, and pulp regeneration, the important modulatory effects of nerves within pulp cavity have been greatly overlooked, making it challenging to achieve functional pulp-dentin complex regeneration. In this study, we propose an injectable bioceramics-containing composite hydrogel in combination of Li-Ca-Si (LCS) bioceramics and gelatin methacrylate matrix with photo-crosslinking properties. Due to the sustained release of bioactive Li, Ca and Si ions from LCS, the composite hydrogels possess multiple functions of promoting the neurogenic differentiation of Schwann cells, odontogenic differentiation of dental pulp stem cells, and neurogenesis-odontogenesis couples in vitro. In addition, the in vivo results showed that LCS-containing composite hydrogel can significantly promote the pulp-dentin complex repair. More importantly, LCS bioceramics-containing composite hydrogel can induce the growth of nerve fibers, leading to the re-innervation of pulp tissues. Taken together, the study suggests that LCS bioceramics can induce the innervation of pulp-dentin complex repair, offering a referable strategy of designing multifunctional filling materials for functional periodontal tissue regeneration.
