Expert consensus on the prevention and treatment of radiochemotherapy-induced oral mucositis.

Juan XIA; Xiaoan TAO; Qinchao HU; Wei LUO; Xiuzhen TONG; Gang ZHOU; Hongmei ZHOU; Hong HUA; Guoyao TANG; Tong WU; Qianming CHEN; Yuan FAN; Xiaobing GUAN; Hongwei LIU; Chaosu HU; Yongmei ZHOU; Xuemin SHEN; Lan WU; Xin ZENG; Qing LIU; Renchuan TAO; Yuan HE; Yang CAI; Wenmei WANG; Ying ZHANG; Yingfang WU; Minhai NIE; Xin JIN; Xiufeng WEI; Yongzhan NIE; Changqing YUAN; Bin CHENG

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Expert consensus on the prevention and treatment of radiochemotherapy-induced oral mucositis.

Author: Juan XIA ¹ ; Xiaoan TAO ¹ ; Qinchao HU ¹ ; Wei LUO ² ; Xiuzhen TONG ³ ; Gang ZHOU ⁴ ; Hongmei ZHOU ⁵ ; Hong HUA ⁶ ; Guoyao TANG ⁷ ; Tong WU ¹ ; Qianming CHEN ⁵ ; Yuan FAN ⁸ ; Xiaobing GUAN ⁹ ; Hongwei LIU ⁶ ; Chaosu HU ¹⁰ ; Yongmei ZHOU ¹¹ ; Xuemin SHEN ¹¹ ; Lan WU ¹¹ ; Xin ZENG ⁵ ; Qing LIU ¹² ; Renchuan TAO ¹³ ; Yuan HE ¹⁴ ; Yang CAI ¹⁵ ; Wenmei WANG ¹⁶ ; Ying ZHANG ¹⁷ ; Yingfang WU ¹⁸ ; Minhai NIE ¹⁹ ; Xin JIN ²⁰ ; Xiufeng WEI ²¹ ; Yongzhan NIE ²² ; Changqing YUAN ²³ ; Bin CHENG ²⁴
Author Information

1. Department of Oral Medicine, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China.
2. Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
3. Department of Hematology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
4. Department of Oral Medicine, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
5. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
6. Department of Oral Medicine, Peking University School and Hospital of Stomatology, Beijing, China.
7. Department of Stomatology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
8. Department of Oral Medicine, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China.
9. Beijing Stomatological Hospital, Capital Medical University, Beijing, China.
10. Department of Radiation Oncology, Fudan University Shanghai Cancer Centre, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
11. Department of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
12. The Third Affiliated Hospital of Air Force Medical University, Xi'an, China.
13. Department of Periodontics and Oral Medicine, College of Stomatology, Guangxi Medical University, Nanning, China.
14. Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Department of Oral Medicine, School of Stomatology, Tongji University, Shanghai, China.
15. Hospital and School of Stomatology, Guizhou Medical University, Guiyang, China.
16. Department of Oral Medicine, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China.
17. Department of Oral Emergency and Mucosal Diseases, School and Hospital of Stomatology, China Medical University, Shenyang, China.
18. Centre of Stomatology, Xiangya Hospital, Cental South University, Changsha, China.
19. Department of Periodontics & Oral Mucosal Diseases, The Affiliated Stomatology Hospital of Southwest Medical University, Luzhou, China.
20. Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, College of Stomatology, Chongqing Medical University, Chongqing, China.
21. School of Stomatology, Jilin University, Changchun, China.
22. State Key Laboratory of Cancer Biology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
23. Department of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.
24. Department of Oral Medicine, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China. chengbin@mail.sysu.edu.cn.
Publication Type:Practice Guideline
MeSH: Humans; Chemoradiotherapy/adverse effects*; Consensus; Risk Factors; Stomatitis/etiology*
From: International Journal of Oral Science 2025;17(1):54-54
CountryChina
Language:English
Abstract: Radiochemotherapy-induced oral mucositis (OM) is a common oral complication in patients with tumors following head and neck radiotherapy or chemotherapy. Erosion and ulcers are the main features of OM that seriously affect the quality of life of patients and even the progress of tumor treatment. To date, differences in clinical prevention and treatment plans for OM have been noted among doctors of various specialties, which has increased the uncertainty of treatment effects. On the basis of current research evidence, this expert consensus outlines risk factors, clinical manifestations, clinical grading, ancillary examinations, diagnostic basis, prevention and treatment strategies and efficacy indicators for OM. In addition to strategies such as basic oral care, anti-inflammatory and analgesic agents, anti-infective agents, pro-healing agents, and photobiotherapy recommended in previous guidelines, we also emphasize the role of traditional Chinese medicine in OM prevention and treatment. This expert consensus aims to provide references and guidance for dental physicians and oncologists in formulating strategies for OM prevention, diagnosis, and treatment, standardizing clinical practice, reducing OM occurrence, promoting healing, and improving the quality of life of patients.