Exploring the mechanical and biological interplay in the periodontal ligament.
10.1038/s41368-025-00354-y
- Author:
Xinyu WEN
1
;
Fang PEI
1
;
Ying JIN
2
;
Zhihe ZHAO
3
Author Information
1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
2. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China. jinying@scu.edu.cn.
3. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China. zhzhao@scu.edu.cn.
- Publication Type:Research Support, Non-U.S. Gov't
- MeSH:
Periodontal Ligament/cytology*;
Humans;
Biomechanical Phenomena;
Mechanotransduction, Cellular/physiology*;
Stress, Mechanical
- From:
International Journal of Oral Science
2025;17(1):23-23
- CountryChina
- Language:English
-
Abstract:
The periodontal ligament (PDL) plays a crucial role in transmitting and dispersing occlusal force, acting as mechanoreceptor for muscle activity during chewing, as well as mediating orthodontic tooth movement. It transforms mechanical stimuli into biological signals, influencing alveolar bone remodeling. Recent research has delved deeper into the biological and mechanical aspects of PDL, emphasizing the importance of understanding its structure and mechanical properties comprehensively. This review focuses on the latest findings concerning both macro- and micro- structural aspects of the PDL, highlighting its mechanical characteristics and factors that influence them. Moreover, it explores the mechanotransduction mechanisms of PDL cells under mechanical forces. Structure-mechanics-mechanotransduction interplay in PDL has been integrated ultimately. By providing an up-to-date overview of our understanding on PDL at various scales, this study lays the foundation for further exploration into PDL-related biomechanics and mechanobiology.
