GenAI synthesis of histopathological images from Raman imaging for intraoperative tongue squamous cell carcinoma assessment.
10.1038/s41368-025-00346-y
- Author:
Bing YAN
1
;
Zhining WEN
2
;
Lili XUE
3
;
Tianyi WANG
1
;
Zhichao LIU
4
;
Wulin LONG
2
;
Yi LI
5
,
6
;
Runyu JING
7
Author Information
1. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Head and Neck Oncology Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
2. College of Chemistry, Sichuan University, Chengdu, China.
3. Department of Stomatology, The first affiliated hospital of Xiamen University, Xiamen, China.
4. Nonclinical Drug Safety, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA.
5. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Head and Neck Oncology Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China. liyi1012@
6. com.
7. School of Cyber Science and Engineering, Sichuan University, Chengdu, China. jingryedu@gmail.com.
- Publication Type:Research Support, Non-U.S. Gov't
- MeSH:
Humans;
Spectrum Analysis, Raman/methods*;
Tongue Neoplasms/diagnostic imaging*;
Carcinoma, Squamous Cell/diagnostic imaging*;
Artificial Intelligence;
Margins of Excision
- From:
International Journal of Oral Science
2025;17(1):12-12
- CountryChina
- Language:English
-
Abstract:
The presence of a positive deep surgical margin in tongue squamous cell carcinoma (TSCC) significantly elevates the risk of local recurrence. Therefore, a prompt and precise intraoperative assessment of margin status is imperative to ensure thorough tumor resection. In this study, we integrate Raman imaging technology with an artificial intelligence (AI) generative model, proposing an innovative approach for intraoperative margin status diagnosis. This method utilizes Raman imaging to swiftly and non-invasively capture tissue Raman images, which are then transformed into hematoxylin-eosin (H&E)-stained histopathological images using an AI generative model for histopathological diagnosis. The generated H&E-stained images clearly illustrate the tissue's pathological conditions. Independently reviewed by three pathologists, the overall diagnostic accuracy for distinguishing between tumor tissue and normal muscle tissue reaches 86.7%. Notably, it outperforms current clinical practices, especially in TSCC with positive lymph node metastasis or moderately differentiated grades. This advancement highlights the potential of AI-enhanced Raman imaging to significantly improve intraoperative assessments and surgical margin evaluations, promising a versatile diagnostic tool beyond TSCC.
