Tongue squamous cell carcinoma-targeting Au-HN-1 nanosystem for CT imaging and photothermal therapy.
10.1038/s41368-024-00343-7
- Author:
Ming HAO
1
;
Xingchen LI
2
;
Xinxin ZHANG
3
;
Boqiang TAO
1
;
He SHI
1
;
Jianing WU
1
;
Yuyang LI
1
;
Xiang LI
1
;
Shuangji LI
1
;
Han WU
1
;
Jingcheng XIANG
1
;
Dongxu WANG
4
;
Weiwei LIU
5
;
Guoqing WANG
6
Author Information
1. Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Jilin University, Changchun, China.
2. State Key Laboratory of Supramolecular Structure and Material, College of Chemistry, Jilin University, Changchun, China.
3. Laboratory Animal Center, College of Animal Science, Jilin University, Changchun, China.
4. Laboratory Animal Center, College of Animal Science, Jilin University, Changchun, China. wang_dong_xu@jlu.edu.cn.
5. Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Jilin University, Changchun, China. liuweiw@jlu.edu.cn.
6. State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, College of Basic Medical Science, Jilin University, Changchun, China. qing@jlu.edu.cn.
- Publication Type:Research Support, Non-U.S. Gov't
- MeSH:
Tongue Neoplasms/diagnostic imaging*;
Carcinoma, Squamous Cell/diagnostic imaging*;
Animals;
Gold/chemistry*;
Mice;
Photothermal Therapy/methods*;
Tomography, X-Ray Computed;
Photosensitizing Agents;
Metal Nanoparticles;
Humans;
Cell Line, Tumor
- From:
International Journal of Oral Science
2025;17(1):9-9
- CountryChina
- Language:English
-
Abstract:
Tongue squamous cell carcinoma (TSCC) is a prevalent malignancy that afflicts the head and neck area and presents a high incidence of metastasis and invasion. Accurate diagnosis and effective treatment are essential for enhancing the quality of life and the survival rates of TSCC patients. The current treatment modalities for TSCC frequently suffer from a lack of specificity and efficacy. Nanoparticles with diagnostic and photothermal therapeutic properties may offer a new approach for the targeted therapy of TSCC. However, inadequate accumulation of photosensitizers at the tumor site diminishes the efficacy of photothermal therapy (PTT). This study modified gold nanodots (AuNDs) with the TSCC-targeting peptide HN-1 to improve the selectivity and therapeutic effects of PTT. The Au-HN-1 nanosystem effectively targeted the TSCC cells and was rapidly delivered to the tumor tissues compared to the AuNDs. The enhanced accumulation of photosensitizing agents at tumor sites achieved significant PTT effects in a mouse model of TSCC. Moreover, owing to its stable long-term fluorescence and high X-ray attenuation coefficient, the Au-HN-1 nanosystem can be used for fluorescence and computed tomography imaging of TSCC, rendering it useful for early tumor detection and accurate delineation of surgical margins. In conclusion, Au-HN-1 represents a promising nanomedicine for imaging-based diagnosis and targeted PTT of TSCC.
