Electrophysiological Signatures of Visual Sensations Elicited by Direct Electrical Stimulation.
10.1007/s12264-025-01464-7
- Author:
Yan-Yan LI
1
;
Bo ZHANG
2
;
Jing WANG
3
;
Yuri B SAALMANN
4
;
Mohsen AFRASIABI
4
;
Peng-Cheng LV
1
;
Hai-Xiang WANG
5
;
Huan-Huan XIANG
3
;
Meng-Yang WANG
3
;
Guo-Ming LUAN
6
;
Robert T KNIGHT
7
;
Liang WANG
8
Author Information
1. State Key Laboratory of Cognitive Science and Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, 100101, China.
2. Key Laboratory of Brain Science, Zunyi Medical University, Zunyi, 563000, China.
3. Department of Neurology, SanBo Brain Hospital, Capital Medical University, Beijing, 100093, China.
4. Department of Psychology, University of Wisconsin-Madison, Madison, 53705, USA.
5. Epilepsy Center, Tsinghua University Yuquan Hospital, Beijing, 100040, China.
6. Department of Neurosurgery, SanBo Brain Hospital, Capital Medical University, Beijing, 100093, China. luangm@ccmu.edu.cn.
7. Helen Wills Neuroscience Institute, University of California, Berkeley, 94720, USA.
8. State Key Laboratory of Cognitive Science and Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, 100101, China. lwang@psych.ac.cn.
- Publication Type:Journal Article
- Keywords:
Electrical stimulation;
Information integration;
Intracranial EEG;
Perception;
Power spectral slope
- MeSH:
Humans;
Male;
Female;
Adult;
Visual Perception/physiology*;
Electric Stimulation;
Middle Aged;
Young Adult;
Electrocorticography;
Electroencephalography;
Brain Mapping
- From:
Neuroscience Bulletin
2025;41(9):1617-1629
- CountryChina
- Language:English
-
Abstract:
Direct electrical stimulation of the human cortex can produce subjective visual sensations, yet these sensations are unstable. The underlying mechanisms may stem from differences in electrophysiological activity within the distributed network outside the stimulated site. To address this problem, we recruited 69 patients who experienced visual sensations during invasive electrical stimulation while intracranial electroencephalography (iEEG) data were recorded. We found significantly flattened power spectral slopes in distributed regions involving different brain networks and decreased integrated information during elicited visual sensations compared with the non-sensation condition. Further analysis based on minimum information partitions revealed that the reconfigured network interactions primarily involved the inferior frontal cortex, posterior superior temporal sulcus, and temporoparietal junction. The flattened power spectral slope in the inferior frontal gyrus was also correlated with integrated information. Taken together, this study indicates that the altered electrophysiological signatures provide insights into the neural mechanisms underlying subjective visual sensations.
