Bridging the Gap: The Neuro-immune Axis as a Key Player in Neurodegenerative Disorders.
10.1007/s12264-025-01439-8
- Author:
Tingting LIU
1
;
Haojie WU
1
;
Jianshe WEI
2
Author Information
1. Institute for Brain Sciences Research, School of Life Sciences, Henan University, Kaifeng, 475004, China.
2. Institute for Brain Sciences Research, School of Life Sciences, Henan University, Kaifeng, 475004, China. jswei@henu.edu.cn.
- Publication Type:Review
- Keywords:
Immune cells;
Immune system;
Nervous system;
Neurodegenerative diseases
- MeSH:
Humans;
Neurodegenerative Diseases/metabolism*;
Animals;
Neuroimmunomodulation/physiology*
- From:
Neuroscience Bulletin
2025;41(10):1867-1887
- CountryChina
- Language:English
-
Abstract:
Neurodegenerative diseases encompass a diverse array of disorders that have a profoundly detrimental impact on human health, characterized by their intricate and multifaceted pathogenesis. In the recent past, a growing body of scientific research has begun to shed light on the critical involvement of the neuro-immune axis in the onset and advancement of these debilitating conditions. This comprehensive review article delves into the intricate composition of the neuro-immune axis, elucidating the complex mechanisms through which it exerts its influence in the context of neurodegenerative diseases. Furthermore, it explores the potential therapeutic applications of targeting the neuro-immune axis for the management and treatment of these diseases. This extensive examination aims to offer new perspectives and innovative strategies that could pave the way for more effective treatments for neurodegenerative diseases, thereby providing hope for those afflicted by these challenging conditions.
