Interoceptive Dysfunction in Psychiatric Disorders and Non-invasive Neuromodulation for Improving Interoception.
10.1007/s12264-025-01432-1
- Author:
Huiru CUI
1
,
2
;
Jijun WANG
3
;
Chunbo LI
3
Author Information
1. Neuromodulation Center, Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China. cuihuiru@
2. com.
3. Neuromodulation Center, Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
- Publication Type:Review
- Keywords:
Insula;
Interoception;
Neuromodulation;
Perception;
Psychiatric disorders
- MeSH:
Humans;
Interoception/physiology*;
Mental Disorders/therapy*
- From:
Neuroscience Bulletin
2025;41(8):1487-1499
- CountryChina
- Language:English
-
Abstract:
Dysfunction of the interoceptive system is recognized as an important component of clinical symptoms, including anxiety, depression, psychosis, and other mental disorders. Non-invasive neuromodulation is an emerging clinical intervention approach, and over the past decade, research on non-invasive neuromodulation aimed at regulating interoception has rapidly developed. This review first outlines the pathways of interoceptive signals and assessment methods, then summarizes the interoceptive abnormalities in psychiatric disorders and current studies for non-invasive neuromodulation targeting interoception, including intervention modes, target sites, interoceptive measures, and potential neurobiological mechanisms. Finally, we discuss significant research challenges and future directions.
